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Schema
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Reaction
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Entries
MMACHC dealkylates RCbl
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authored
[InstanceEdit:196747] Jassal, B, 2007年04月24日 08:38:46
catalystActivity
[CatalystActivity:3245899] transferase activity, transferring alkyl or aryl (other than methyl) groups of MMACHC [cytosol]
catalystActivityReference
[CatalystActivityReference:9759560] transferase activity, transferring alkyl or aryl (other than methyl) groups of MMACHC [cytosol] A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:3095883] Jassal, Bijay, 2013年02月08日
crossReference
[DatabaseIdentifier:9908091] RHEA:40720
dbId
3095889
displayName
MMACHC dealkylates RCbl
edited
[InstanceEdit:3095883] Jassal, Bijay, 2013年02月08日
eventOf
[Pathway:R-HSA-9759218] Cobalamin (Cbl) metabolism - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin - Homo sapiens
input
[SimpleEntity:R-ALL-29450] GSH [cytosol]
[EntityWithAccessionedSequence:R-HSA-2980949] MMACHC [cytosol]
[SimpleEntity:R-ALL-9759394] RCbl [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:3149507] Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product
[LiteratureReference:9759558] A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins
[LiteratureReference:9759557] Structural basis of multifunctionality in a vitamin B12-processing enzyme
[LiteratureReference:3095895] Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type
maxDepth
1
modified
[InstanceEdit:10948619] Weiser, Joel, 2025年08月27日
name
MMACHC dealkylates RCbl
an R-cob(III)alamin + apo--(alkylcobalamin reductase) + glutathione => an S-substituted glutathione + cob(I)alamin--(alkylcobalamin reductase) + H(+)
negativePrecedingEvent
[NegativePrecedingEvent:9764873] Different Cell Type: ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells)
[NegativePrecedingEvent:9764885] Incorrect Order: MMADHC targets transport of cytosolic cob(II)alamin to mitochondria
[NegativePrecedingEvent:9764876] Incorrect Order: cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR
orthologousEvent
[Reaction:R-BTA-3095889] MMACHC dealkylates RCbl - Bos taurus
[Reaction:R-DDI-3095889] MMACHC dealkylates RCbl - Dictyostelium discoideum
[Reaction:R-CEL-3095889] MMACHC dealkylates RCbl - Caenorhabditis elegans
[Reaction:R-GGA-3095889] MMACHC dealkylates RCbl - Gallus gallus
[Reaction:R-XTR-3095889] MMACHC dealkylates RCbl - Xenopus tropicalis
[Reaction:R-DRE-3095889] MMACHC dealkylates RCbl - Danio rerio
[Reaction:R-SSC-3095889] MMACHC dealkylates RCbl - Sus scrofa
[Reaction:R-CFA-3095889] MMACHC dealkylates RCbl - Canis familiaris
[Reaction:R-RNO-3095889] MMACHC dealkylates RCbl - Rattus norvegicus
[Reaction:R-MMU-3095889] MMACHC dealkylates RCbl - Mus musculus
output
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[Complex:R-HSA-9759561] MMACHC:cob(I)alamin [cytosol]
[SimpleEntity:R-ALL-9759438] R-GSH [cytosol]
precedingEvent
[Reaction:R-HSA-9759206] ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol - Homo sapiens
releaseDate
2013年06月11日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:3288227] D'Eustachio, P, 2013年04月15日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-3095889
summation
[Summation:3095880] MMACHC (Methylmalonic aciduria and homocystinuria type C pro...
updateTrackers
[UpdateTracker:9787276] Update Tracker - [Reaction:3095889] MMACHC dealkylates RCbl - v46:[modifyText]
[UpdateTracker:9786179] Update Tracker - [Reaction:3095889] MMACHC dealkylates RCbl - v50:[modifyText]
[UpdateTracker:9775197] Update Tracker - [Reaction:3095889] MMACHC dealkylates RCbl - v80:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9787276] Update Tracker - [Reaction:3095889] MMACHC dealkylates RCbl - v46:[modifyText]
[UpdateTracker:9786179] Update Tracker - [Reaction:3095889] MMACHC dealkylates RCbl - v50:[modifyText]
[UpdateTracker:9775197] Update Tracker - [Reaction:3095889] MMACHC dealkylates RCbl - v80:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
(normalReaction)
[FailedReaction:R-HSA-3318576] Defective MMACHC does not reduce Cbl
(hasEvent)
[Pathway:R-HSA-9759218] Cobalamin (Cbl) metabolism
(precedingEvent)
[BlackBoxEvent:R-HSA-9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin
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