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Go!
Schema
>
Complex
>
Entries
spherical HDL [extracellular region]
Show undefined attributes
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candidateOf
[CandidateSet:R-HSA-9707486] LDL,HDL [extracellular region] - Homo sapiens
compartment
[Compartment:984] extracellular region
componentOf
[Complex:R-HSA-266348] spherical HDL:triacylglycerol complex [extracellular region] - Homo sapiens
[Complex:R-HSA-8858255] HDLBP:HDL [plasma membrane] - Homo sapiens
consumedByEvent
[Reaction:R-HSA-266299] Spherical HDL binds membrane-associated free cholesterol and phospholipids - Homo sapiens
[Reaction:R-HSA-8858252] HDLBP binds HDL - Homo sapiens
[Reaction:R-HSA-174690] TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III - Homo sapiens
[Reaction:R-HSA-349404] CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex - Homo sapiens
[Reaction:R-HSA-266315] LCAT + spherical HDL <=> LCAT:spherical HDL complex - Homo sapiens
[Reaction:R-HSA-266328] CETP-mediated lipid exchange: spherical HDL gains triacylglycerol - Homo sapiens
[Reaction:R-HSA-349637] spherical HDL and SR-BI receptor form a complex at the cell surface - Homo sapiens
[Reaction:R-HSA-266303] Spherical HDL binds C and E apolipoproteins - Homo sapiens
dbId
265523
deleted
[Deleted:8964441] Deletion of instance: 174713
displayName
spherical HDL [extracellular region]
goCellularComponent
[GO_CellularComponent:266314] spherical high-density lipoprotein particle
hasComponent
4 ×
[EntityWithAccessionedSequence:R-HSA-174720] APOA1(25-266) [extracellular region]
160 ×
[SimpleEntity:R-ALL-171076] CHEST [extracellular region]
40 ×
[SimpleEntity:R-ALL-171149] CHOL [extracellular region]
140 ×
[SimpleEntity:R-ALL-171066] PL [extracellular region]
20 ×
[SimpleEntity:R-ALL-171126] TAGs [extracellular region]
inDisease
false
inferredTo
[Complex:R-MMU-265523] spherical HDL [extracellular region] - Mus musculus
[Complex:R-RNO-265523] spherical HDL [extracellular region] - Rattus norvegicus
[Complex:R-CFA-265523] spherical HDL [extracellular region] - Canis familiaris
[Complex:R-BTA-265523] spherical HDL [extracellular region] - Bos taurus
[Complex:R-SSC-265523] spherical HDL [extracellular region] - Sus scrofa
[Complex:R-DRE-265523] spherical HDL [extracellular region] - Danio rerio
[Complex:R-GGA-265523] spherical HDL [extracellular region] - Gallus gallus
literatureReference
[LiteratureReference:194265] Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis
maxDepth
2
memberOf
[DefinedSet:R-HSA-2197637] Ligands of SCARB1 [extracellular region] - Homo sapiens
[DefinedSet:R-HSA-2187232] Ligands of CD36 [extracellular region] - Homo sapiens
modified
[InstanceEdit:9963749] Weiser, Joel, 2025年08月15日
name
spherical HDL
spherical high-density lipoprotein
mature high-density lipoprotein
producedByEvent
[BlackBoxEvent:R-HSA-2395784] Nascent CMs transform into mature CMs - Homo sapiens
[Reaction:R-HSA-266310] LCAT:spherical HDL complex <=> LCAT + spherical HDL - Homo sapiens
[Reaction:R-HSA-174660] nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron - Homo sapiens
schemaClass
Complex
species
[Species:48887] Homo sapiens
stId
R-HSA-265523
Referrals
(replacementInstances)
[Deleted:8964441] Deletion of instance: 174713
(output)
[BlackBoxEvent:R-HSA-2395784] Nascent CMs transform into mature CMs
[Reaction:R-HSA-266310] LCAT:spherical HDL complex <=> LCAT + spherical HDL
[Reaction:R-HSA-174660] nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron
(hasComponent)
[Complex:R-HSA-8858255] HDLBP:HDL [plasma membrane]
[Complex:R-HSA-174769] spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region]
[Complex:R-HSA-349410] CETP:spherical HDL:torcetrapib complex [extracellular region]
[Complex:R-HSA-266308] LCAT:spherical HDL complex [extracellular region]
[Complex:R-HSA-266348] spherical HDL:triacylglycerol complex [extracellular region]
[Complex:R-HSA-174643] spherical HDL:apoC-II:apoC-III:apoE [extracellular region]
(input)
[Reaction:R-HSA-8858252] HDLBP binds HDL
[Reaction:R-HSA-174690] TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III
[Reaction:R-HSA-266299] Spherical HDL binds membrane-associated free cholesterol and phospholipids
[Reaction:R-HSA-266303] Spherical HDL binds C and E apolipoproteins
[Reaction:R-HSA-349404] CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex
[Reaction:R-HSA-266315] LCAT + spherical HDL <=> LCAT:spherical HDL complex
[Reaction:R-HSA-266328] CETP-mediated lipid exchange: spherical HDL gains triacylglycerol
[Reaction:R-HSA-349637] spherical HDL and SR-BI receptor form a complex at the cell surface
(hasMember)
[DefinedSet:R-HSA-2197637] Ligands of SCARB1 [extracellular region]
[DefinedSet:R-HSA-2187232] Ligands of CD36 [extracellular region]
(hasCandidate)
[CandidateSet:R-HSA-9707486] LDL,HDL [extracellular region]
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