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Entries
Oncogene Induced Senescence
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authored
[InstanceEdit:3900006] Orlic-Milacic, M, 2013年07月15日
created
[InstanceEdit:2559581] Orlic-Milacic, M, 2012年11月02日
crossReference
[DatabaseIdentifier:12757990] BioModels Database:BIOMD0000000189
dbId
2559585
diseasePathways
[Pathway:R-HSA-9646303] Evasion of Oncogene Induced Senescence Due to p14ARF Defects - Homo sapiens
[Pathway:R-HSA-9630794] Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 - Homo sapiens
[Pathway:R-HSA-9630791] Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 - Homo sapiens
displayName
Oncogene Induced Senescence
edited
[InstanceEdit:3901124] D'Eustachio, P, 2013年07月15日
[InstanceEdit:4542306] Matthews, L, 2013年07月15日
eventOf
[Pathway:R-HSA-2559583] Cellular Senescence - Homo sapiens
figure
[Figure:5693884] /figures/Pathway_Illustrations/illustration_senescence_oncogene_72.png
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-3132737] MAPKs phosphorylate ETS1 and ETS2 - Homo sapiens
[Reaction:R-HSA-3200023] Phosphorylated ETS1 binds p16INK4A promoter - Homo sapiens
[Reaction:R-HSA-8979082] Phosphorylated ETS2 binds p16INK4A promoter - Homo sapiens
[BlackBoxEvent:R-HSA-3209098] p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA - Homo sapiens
[Reaction:R-HSA-3209165] ID1 sequesters ETS2 - Homo sapiens
[Reaction:R-HSA-3209177] ERF binds ETS2 promoter - Homo sapiens
[BlackBoxEvent:R-HSA-3209179] ERF inhibits ETS2 expression - Homo sapiens
[Reaction:R-HSA-3209160] Activated ERKs phosphorylate ERF - Homo sapiens
[Reaction:R-HSA-3209159] Phosphorylated ERF translocates to the cytosol - Homo sapiens
[Reaction:R-HSA-182594] Association of INK4 family proteins with CDK4/6 - Homo sapiens
[Reaction:R-HSA-3209096] E2F1, E2F2, or E2F3 and SP1 bind p14ARF promoter - Homo sapiens
[BlackBoxEvent:R-HSA-3209109] E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA - Homo sapiens
[Reaction:R-HSA-3209151] miR-24 binds p16INK4A and p14ARF mRNAs - Homo sapiens
[BlackBoxEvent:R-HSA-3209111] Translation of p14ARF mRNA is inhibited by miR-24 - Homo sapiens
[BlackBoxEvent:R-HSA-3209114] Translation of p16INK4A mRNA is inhibited by miR-24 - Homo sapiens
[Reaction:R-HSA-6804879] MDM2 ubiquitinates TP53 - Homo sapiens
[BlackBoxEvent:R-HSA-9645672] p14ARF translocates to the nucleus - Homo sapiens
[Reaction:R-HSA-6804998] p14ARF forms a ternary complex with MDM2 and TP53 - Homo sapiens
[Reaction:R-HSA-6804996] p14ARF sequesters MDM2 - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2019年12月10日
literatureReference
[LiteratureReference:3209145] p16(INK4a) translation suppressed by miR-24
[LiteratureReference:3209136] Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development
[LiteratureReference:182601] A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
[LiteratureReference:3209191] ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
[LiteratureReference:3215309] Mdm2 association with p53 targets its ubiquitination
[LiteratureReference:3245948] The p53-mdm-2 autoregulatory feedback loop
[LiteratureReference:3215306] Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
[LiteratureReference:3132729] Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2
[LiteratureReference:3132718] An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors
[LiteratureReference:3166783] Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment
[LiteratureReference:3166776] Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP
[LiteratureReference:3200021] Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
[LiteratureReference:3209175] ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation
[LiteratureReference:3209161] ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression
[LiteratureReference:3209099] Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors
[LiteratureReference:4608746] Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence
[LiteratureReference:4608743] Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth
[LiteratureReference:4608731] Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b)
[LiteratureReference:4650040] Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model
[LiteratureReference:8862796] Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
[LiteratureReference:9633902] Forging a signature of in vivo senescence
[LiteratureReference:9645245] Detection of Oncogene-Induced Senescence In Vivo
maxDepth
2
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Oncogene Induced Senescence
orthologousEvent
[Pathway:R-CFA-2559585] Oncogene Induced Senescence - Canis familiaris
[Pathway:R-MMU-2559585] Oncogene Induced Senescence - Mus musculus
[Pathway:R-SSC-2559585] Oncogene Induced Senescence - Sus scrofa
[Pathway:R-GGA-2559585] Oncogene Induced Senescence - Gallus gallus
[Pathway:R-XTR-2559585] Oncogene Induced Senescence - Xenopus tropicalis
[Pathway:R-DME-2559585] Oncogene Induced Senescence - Drosophila melanogaster
[Pathway:R-CEL-2559585] Oncogene Induced Senescence - Caenorhabditis elegans
[Pathway:R-BTA-2559585] Oncogene Induced Senescence - Bos taurus
[Pathway:R-DRE-2559585] Oncogene Induced Senescence - Danio rerio
[Pathway:R-RNO-2559585] Oncogene Induced Senescence - Rattus norvegicus
releaseDate
2013年09月18日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:4542303] Samarajiwa, Shamith, 2013年09月03日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-2559585
summation
[Summation:3245961] Oncogene-induced senescence (OIS) is triggered by high level...
updateTrackers
[UpdateTracker:9782720] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v58:[add_removeHasEvent]
[UpdateTracker:9783297] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v57:[addLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9782586] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v59:[updateContainedRLE]
[UpdateTracker:9777753] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v69:[addLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9781664] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v60:[addHasEvent, updateContainedRLE]
[UpdateTracker:9786858] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v47:[addLiteratureReference, modifyText]
[UpdateTracker:9777594] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v70:[addHasEvent, updateContainedRLE]
[UpdateTracker:9777466] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v71:[updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-2559583] Cellular Senescence
(hasEncapsulatedEvent)
[Pathway:R-HSA-453279] Mitotic G1 phase and G1/S transition
[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence
[Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence
[Pathway:R-HSA-8853884] Transcriptional Regulation by VENTX
[Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP)
(normalPathway)
[Pathway:R-HSA-9646303] Evasion of Oncogene Induced Senescence Due to p14ARF Defects
[Pathway:R-HSA-9630794] Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
[Pathway:R-HSA-9630791] Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
(updatedInstance)
[UpdateTracker:9782720] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v58:[add_removeHasEvent]
[UpdateTracker:9783297] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v57:[addLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9782586] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v59:[updateContainedRLE]
[UpdateTracker:9777753] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v69:[addLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9781664] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v60:[addHasEvent, updateContainedRLE]
[UpdateTracker:9786858] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v47:[addLiteratureReference, modifyText]
[UpdateTracker:9777594] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v70:[addHasEvent, updateContainedRLE]
[UpdateTracker:9777466] Update Tracker - [Pathway:2559585] Oncogene Induced Senescence - v71:[updateContainedRLE]
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