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Schema
>
Reaction
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Entries
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT
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authored
[InstanceEdit:2272794] Garapati, P V, 2012年05月25日
category
binding
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:2396559] Garapati, P V, 2012年07月09日
dbId
2396606
displayName
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT
edited
[InstanceEdit:2272794] Garapati, P V, 2012年05月25日
eventOf
[Pathway:R-HSA-2871796] FCERI mediated MAPK activation - Homo sapiens
[Pathway:R-HSA-2424491] DAP12 signaling - Homo sapiens
followingEvent
[Reaction:R-HSA-2396594] Phosphorylation of SLP-76 by p-SYK - Homo sapiens
input
[Complex:R-HSA-2424464] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane]
[DefinedSet:R-HSA-1169089] PLC gamma1,2 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:202315] Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.
[LiteratureReference:202293] Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT
[LiteratureReference:2396593] TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1
[LiteratureReference:2685365] Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT
orthologousEvent
[Reaction:R-BTA-2396606] Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT - Bos taurus
[Reaction:R-DME-2396606] Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT - Drosophila melanogaster
[Reaction:R-GGA-2396606] Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT - Gallus gallus
[Reaction:R-XTR-2396606] Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT - Xenopus tropicalis
[Reaction:R-SSC-2396606] Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT - Sus scrofa
[Reaction:R-CFA-2396606] Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT - Canis familiaris
[Reaction:R-RNO-2396606] Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT - Rattus norvegicus
[Reaction:R-MMU-2396606] Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT - Mus musculus
output
[Complex:R-HSA-2396571] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane]
precedingEvent
[Reaction:R-HSA-2396561] Recruitment of GADS:SLP-76 to p-5Y-LAT - Homo sapiens
releaseDate
2012年09月18日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2428957] Lanier, Lewis L, 2012年08月09日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2396606
summation
[Summation:2396580] The phospholipase PLC-gamma is an important mediator of TCR,...
updateTrackers
[UpdateTracker:9787528] Update Tracker - [Reaction:2396606] Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT - v44:[addLiteratureReference, add_removeInput, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9787528] Update Tracker - [Reaction:2396606] Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT - v44:[addLiteratureReference, add_removeInput, modifyText]
(hasEvent)
[Pathway:R-HSA-2424491] DAP12 signaling
[Pathway:R-HSA-2871796] FCERI mediated MAPK activation
(precedingEvent)
[Reaction:R-HSA-2396594] Phosphorylation of SLP-76 by p-SYK
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