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Reaction
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Entries
miR-26A microRNAs bind PTEN mRNA
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authored
[InstanceEdit:2422427] Orlic-Milacic, M, 2012年07月18日
category
binding
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:2318748] Orlic-Milacic, M, 2012年06月15日
dbId
2318752
displayName
miR-26A microRNAs bind PTEN mRNA
edited
[InstanceEdit:2426555] Matthews, L, 2012年08月03日
eventOf
[Pathway:R-HSA-8943723] Regulation of PTEN mRNA translation - Homo sapiens
[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-8944497] PTEN mRNA translation is negatively regulated by microRNAs - Homo sapiens
[BlackBoxEvent:R-HSA-2321904] PTEN mRNA translation negatively regulated by microRNAs - Homo sapiens
input
[DefinedSet:R-HSA-2318737] miR-26A RISC [cytosol]
[EntityWithAccessionedSequence:R-HSA-2318746] PTEN mRNA [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:2318761] The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
[LiteratureReference:2325197] Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
miR-26A microRNAs bind PTEN mRNA
output
[Complex:R-HSA-2318750] PTEN mRNA:miR-26A RISC [cytosol]
precedingEvent
[BlackBoxEvent:R-HSA-5632993] PTEN gene transcription is stimulated by TP53 - Homo sapiens
[BlackBoxEvent:R-HSA-8944104] PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN - Homo sapiens
releaseDate
2012年09月18日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2463860] Thorpe, Lauren, 2012年08月13日
[InstanceEdit:2463859] Yuzugullu, Haluk, 2012年08月13日
[InstanceEdit:2463854] Zhao, Jean J, 2012年08月13日
[InstanceEdit:8948085] Leslie, Nicholas, 2016年09月30日
[InstanceEdit:8948084] Kriplani, Nisha, 2016年09月30日
[InstanceEdit:8948082] Carracedo, Arkaitz, 2016年08月11日
[InstanceEdit:8948087] Salmena, Leonardo, 2016年08月11日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2318752
summation
[Summation:2321900] MIR26A microRNAs, miR-26A1 and miR-26A2, transcribed from ge...
updateTrackers
[UpdateTracker:9783924] Update Tracker - [Reaction:2318752] miR-26A microRNAs bind PTEN mRNA - v55:[modifyText]
[UpdateTracker:9782326] Update Tracker - [Reaction:2318752] miR-26A microRNAs bind PTEN mRNA - v59:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9783924] Update Tracker - [Reaction:2318752] miR-26A microRNAs bind PTEN mRNA - v55:[modifyText]
[UpdateTracker:9782326] Update Tracker - [Reaction:2318752] miR-26A microRNAs bind PTEN mRNA - v59:[modifyText]
(hasEvent)
[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes
[Pathway:R-HSA-8943723] Regulation of PTEN mRNA translation
(precedingEvent)
[BlackBoxEvent:R-HSA-8944497] PTEN mRNA translation is negatively regulated by microRNAs
[BlackBoxEvent:R-HSA-2321904] PTEN mRNA translation negatively regulated by microRNAs
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