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Schema
>
Reaction
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Entries
PPM1A protein phosphatase binds phosphorylated SMAD2/3
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authored
[InstanceEdit:2186634] Orlic-Milacic, M, 2012年04月04日
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:2187391] Orlic-Milacic, M, 2012年04月09日
dbId
2187388
displayName
PPM1A protein phosphatase binds phosphorylated SMAD2/3
edited
[InstanceEdit:2187413] Jassal, B, 2012年04月10日
[InstanceEdit:9773750] Orlic-Milacic, Marija, 2022年05月09日
eventOf
[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Homo sapiens
followingEvent
[Reaction:R-HSA-209055] PPM1A dephosphorylates nuclear SMAD2/3 - Homo sapiens
input
[DefinedSet:R-HSA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-205813] PPM1A [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:208080] PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
PPM1A protein phosphatase binds phosphorylated SMAD2/3
negativePrecedingEvent
[NegativePrecedingEvent:9754417] Futile Cycle: PPM1A dephosphorylates nuclear SMAD2/3
[NegativePrecedingEvent:9754433] Futile Cycle: Ubiquitination of SKI/SKIL by RNF111/SMURF2
orthologousEvent
[Reaction:R-CEL-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 - Caenorhabditis elegans
[Reaction:R-DME-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 - Drosophila melanogaster
[Reaction:R-SSC-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 - Sus scrofa
[Reaction:R-BTA-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 - Bos taurus
[Reaction:R-CFA-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 - Canis familiaris
[Reaction:R-RNO-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 - Rattus norvegicus
[Reaction:R-MMU-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 - Mus musculus
output
[Complex:R-HSA-2187392] p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2250308] Huang, Tao, 2012年05月14日
[InstanceEdit:9773670] Contreras, Osvaldo, 2022年05月02日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2187388
summation
[Summation:2187389] PPM1A protein phosphatase binds phosphorylated SMAD2 and SMA...
Referrals
(hasEvent)
[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity
(precedingEvent)
[Reaction:R-HSA-209055] PPM1A dephosphorylates nuclear SMAD2/3
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