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Schema
>
Reaction
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Entries
PARP1 binds SMAD2/3:SMAD4 heterotrimer
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authored
[InstanceEdit:2186634] Orlic-Milacic, M, 2012年04月04日
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:2187320] Orlic-Milacic, M, 2012年04月09日
dbId
2187330
displayName
PARP1 binds SMAD2/3:SMAD4 heterotrimer
edited
[InstanceEdit:2187413] Jassal, B, 2012年04月10日
[InstanceEdit:9773750] Orlic-Milacic, Marija, 2022年05月09日
eventOf
[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Homo sapiens
followingEvent
[Reaction:R-HSA-2187325] PARP1 ADP-ribosylates SMAD3 and SMAD4 - Homo sapiens
input
[DefinedSet:R-HSA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-201568] PARP1 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:2187315] PARP-1 attenuates Smad-mediated transcription
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
PARP1 binds SMAD2/3:SMAD4 heterotrimer
negativePrecedingEvent
[NegativePrecedingEvent:9754407] Futile Cycle: PARP1 ADP-ribosylates SMAD3 and SMAD4
[NegativePrecedingEvent:9754421] Futile Cycle: Ubiquitination of SKI/SKIL by RNF111/SMURF2
orthologousEvent
[Reaction:R-DME-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer - Drosophila melanogaster
[Reaction:R-SSC-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer - Sus scrofa
[Reaction:R-BTA-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer - Bos taurus
[Reaction:R-CFA-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer - Canis familiaris
[Reaction:R-RNO-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer - Rattus norvegicus
[Reaction:R-MMU-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer - Mus musculus
output
[Complex:R-HSA-2187322] p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2250308] Huang, Tao, 2012年05月14日
[InstanceEdit:9773670] Contreras, Osvaldo, 2022年05月02日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2187330
summation
[Summation:2187312] PARP1 (poly [ADP-ribose] polymerase 1) binds SMAD2/3:SMAD4 h...
Referrals
(hasEvent)
[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity
(precedingEvent)
[Reaction:R-HSA-2187325] PARP1 ADP-ribosylates SMAD3 and SMAD4
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