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SMAD2/3:SMAD4 heterotrimer binds SP1 Show undefined attributes

authored

[InstanceEdit:2186634] Orlic-Milacic, M, 2012年04月04日

category binding

compartment

[Compartment:7660] nucleoplasm

created [InstanceEdit:2187306] Orlic-Milacic, M, 2012年04月09日

dbId 2187309

displayName SMAD2/3:SMAD4 heterotrimer binds SP1

edited

eventOf

[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Homo sapiens

followingEvent

[Reaction:R-HSA-9736979] p-2S-SMAD2,3:SMAD4:SP1 binds CDKN2B gene promoter - Homo sapiens

input

isChimeric false

isInDisease false

isInferred false

literatureReference

[LiteratureReference:1181277] Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta

maxDepth 1

modified [InstanceEdit:10778922] Weiser, Joel, 2025年08月27日

name

SMAD2/3:SMAD4 heterotrimer binds SP1

negativePrecedingEvent

[NegativePrecedingEvent:9754423] Futile Cycle: Ubiquitination of SKI/SKIL by RNF111/SMURF2

orthologousEvent

output

[Complex:R-HSA-2187302] p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm]

precedingEvent

[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens

releaseDate 2012年06月12日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-2187309

summation

[Summation:2187308] TGF-beta (TGFB1) stimulates formation of a complex of SP1 tr...

Referrals

(hasEvent)

[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

(precedingEvent)

[Reaction:R-HSA-9736979] p-2S-SMAD2,3:SMAD4:SP1 binds CDKN2B gene promoter

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