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Schema
>
Pathway
>
Entries
Xenobiotics
Show undefined attributes
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authored
[InstanceEdit:350358] Jassal, Bijay, 2008年05月19日
compartment
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:17957] endoplasmic reticulum lumen
created
[InstanceEdit:211969] Jassal, B, 2008年02月08日 15:33:52
dbId
211981
displayName
Xenobiotics
edited
[InstanceEdit:350358] Jassal, Bijay, 2008年05月19日
eventOf
[Pathway:R-HSA-211897] Cytochrome P450 - arranged by substrate type - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:8764] xenobiotic metabolic process
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-76472] Ethylene is oxidized to Ethylene oxide by CYP1A1 - Homo sapiens
[Pathway:R-HSA-211957] Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 - Homo sapiens
[Reaction:R-HSA-76453] Coumarin is 7-hydroxylated by CYP2A6 - Homo sapiens
[Reaction:R-HSA-211881] Coumarin is 7-hydroxylated by CYP2A13 - Homo sapiens
[Reaction:R-HSA-211991] Cyclophosphamide is 4-hydroxylated by CYP2B6 - Homo sapiens
[Reaction:R-HSA-211910] CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation - Homo sapiens
[Reaction:R-HSA-211988] CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation - Homo sapiens
[Reaction:R-HSA-212004] CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation - Homo sapiens
[Reaction:R-HSA-211929] CYP2C19 5-hydroxylates omeprazole - Homo sapiens
[Pathway:R-HSA-211999] CYP2E1 reactions - Homo sapiens
[Reaction:R-HSA-76456] O-atom dealkylation of dextromethorphan - Homo sapiens
[Reaction:R-HSA-211966] CYP2D6 4-hydroxylates debrisoquine - Homo sapiens
[Reaction:R-HSA-212005] CYP2F1 dehydrogenates 3-methylindole - Homo sapiens
[Reaction:R-HSA-211948] CYP3A4 can N-demethylate loperamide - Homo sapiens
[Reaction:R-HSA-213175] CYP3A4,5 oxidise AFB1 to AFXBO - Homo sapiens
[Reaction:R-HSA-211882] CYP3A7 can 6beta-hydroxylate testosterone - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2023年09月13日
literatureReference
[LiteratureReference:266185] 57 varieties: the human cytochromes P450
[LiteratureReference:266174] Cytochrome P450s and other enzymes in drug metabolism and toxicity
[LiteratureReference:266241] The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans
maxDepth
3
modified
[InstanceEdit:10948619] Weiser, Joel, 2025年08月27日
name
Xenobiotics
orthologousEvent
[Pathway:R-DDI-211981] Xenobiotics - Dictyostelium discoideum
[Pathway:R-CEL-211981] Xenobiotics - Caenorhabditis elegans
[Pathway:R-DME-211981] Xenobiotics - Drosophila melanogaster
[Pathway:R-GGA-211981] Xenobiotics - Gallus gallus
[Pathway:R-XTR-211981] Xenobiotics - Xenopus tropicalis
[Pathway:R-DRE-211981] Xenobiotics - Danio rerio
[Pathway:R-SSC-211981] Xenobiotics - Sus scrofa
[Pathway:R-BTA-211981] Xenobiotics - Bos taurus
[Pathway:R-CFA-211981] Xenobiotics - Canis familiaris
[Pathway:R-RNO-211981] Xenobiotics - Rattus norvegicus
[Pathway:R-MMU-211981] Xenobiotics - Mus musculus
releaseDate
2008年06月30日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:351775] D'Eustachio, P, 2008年05月28日 08:30:54
revised
[InstanceEdit:350358] Jassal, Bijay, 2008年05月19日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-211981
summation
[Summation:266251] Of the 50 microsomal CYPs, 15 act on xenobiotics. They all p...
updateTrackers
[UpdateTracker:9842261] Update Tracker - [Pathway:211981] Xenobiotics - v86:[updateContainedRLE]
[UpdateTracker:9791582] Update Tracker - [Pathway:211981] Xenobiotics - v28:[updateIndirectRLE]
[UpdateTracker:9782448] Update Tracker - [Pathway:211981] Xenobiotics - v59:[updateContainedRLE]
[UpdateTracker:9791713] Update Tracker - [Pathway:211981] Xenobiotics - v27:[updateContainedRLE]
[UpdateTracker:9786561] Update Tracker - [Pathway:211981] Xenobiotics - v49:[updateContainedRLE]
[UpdateTracker:9790555] Update Tracker - [Pathway:211981] Xenobiotics - v33:[addHasEvent, updateIndirectRLE]
[UpdateTracker:9778773] Update Tracker - [Pathway:211981] Xenobiotics - v67:[updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9842261] Update Tracker - [Pathway:211981] Xenobiotics - v86:[updateContainedRLE]
[UpdateTracker:9791582] Update Tracker - [Pathway:211981] Xenobiotics - v28:[updateIndirectRLE]
[UpdateTracker:9782448] Update Tracker - [Pathway:211981] Xenobiotics - v59:[updateContainedRLE]
[UpdateTracker:9791713] Update Tracker - [Pathway:211981] Xenobiotics - v27:[updateContainedRLE]
[UpdateTracker:9786561] Update Tracker - [Pathway:211981] Xenobiotics - v49:[updateContainedRLE]
[UpdateTracker:9790555] Update Tracker - [Pathway:211981] Xenobiotics - v33:[addHasEvent, updateIndirectRLE]
[UpdateTracker:9778773] Update Tracker - [Pathway:211981] Xenobiotics - v67:[updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-211897] Cytochrome P450 - arranged by substrate type
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