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Dimerization of FGFR3 point mutants with enhanced kinase activity Show undefined attributes

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authored

[InstanceEdit:2105031] Rothfels, K, 2012年02月09日

category transition

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:2033477] Rothfels, K, 2012年01月09日

crossReference

dbId 2033476

disease

displayName Dimerization of FGFR3 point mutants with enhanced kinase activity

edited

[InstanceEdit:2252592] Rothfels, K, 2012年05月16日

entityFunctionalStatus

[EntityFunctionalStatus:5654492] gain_of_function of FGFR3 point mutants with enhanced kinase activity [plasma membrane]

eventOf

[Pathway:R-HSA-1839130] Signaling by activated point mutants of FGFR3 - Homo sapiens

followingEvent

[Reaction:R-HSA-2033485] Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity - Homo sapiens

input

2 × [CandidateSet:R-HSA-2018770] FGFR3 point mutants with enhanced kinase activity [plasma membrane]

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Dimerization of FGFR3 point mutants with enhanced kinase activity

output

[CandidateSet:R-HSA-2033383] FGFR3 point mutant dimers with enhanced kinase activity [plasma membrane]

releaseDate 2012年06月12日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:2248845] Ezzat, S, 2012年05月15日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-2033476

summation

[Summation:2065320] Activating point mutations G380R, N540K and K650E/M/N/Q in F...

Referrals

(hasEvent)

[Pathway:R-HSA-1839130] Signaling by activated point mutants of FGFR3

(precedingEvent)

[Reaction:R-HSA-2033485] Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity

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