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Generation of second messenger molecules
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authored
[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008年01月24日 15:53:10
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:202434] Garapati, P V, 2007年10月29日 15:25:21
crossReference
[DatabaseIdentifier:12757954] BioModels Database:BIOMD0000000724
dbId
202433
displayName
Generation of second messenger molecules
eventOf
[Pathway:R-HSA-202403] TCR signaling - Homo sapiens
figure
[Figure:9689488] /figures/static/R-HSA-202433.svg
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-202245] Phosphorylation of TBSMs in LAT - Homo sapiens
[Reaction:R-HSA-202325] Recruitment of Gads to LAT - Homo sapiens
[Reaction:R-HSA-202241] Recruitment of SLP-76 to Gads - Homo sapiens
[Reaction:R-HSA-202216] Phosphorylation of SLP-76 - Homo sapiens
[Reaction:R-HSA-202375] Recruitment of ITK to SLP-76 - Homo sapiens
[Reaction:R-HSA-202331] Recruitment of PLC-gamma1 to SLP-76 - Homo sapiens
[Reaction:R-HSA-202212] Recruitment of PLC-gamma1 to LAT - Homo sapiens
[Reaction:R-HSA-202248] Phosphorylation of PLC-gamma1 - Homo sapiens
[Reaction:R-HSA-213406] Disassociation of PLC-gamma1 from LAT - Homo sapiens
[Reaction:R-HSA-213407] Disassociation of PLC-gamma1 from SLP-76 - Homo sapiens
[Reaction:R-HSA-202354] Translocation of PLC-gamma1 to PIP2 - Homo sapiens
[Reaction:R-HSA-202407] PLC-gamma1 hydrolyses PIP2 - Homo sapiens
[Reaction:R-HSA-430135] p-SLP-76 binds ADAP - Homo sapiens
[Reaction:R-HSA-430201] p-SLP-76:ADAP binds Ena/VASP - Homo sapiens
[Reaction:R-HSA-430190] p-SLP-76 binds NCK - Homo sapiens
[Reaction:R-HSA-430183] NCK binds PAK - Homo sapiens
[Reaction:R-HSA-430180] NCK recruits WASP - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2021年09月15日
literatureReference
[LiteratureReference:202217] T cell receptor signaling: beyond complex complexes
maxDepth
2
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
Generation of second messenger molecules
orthologousEvent
[Pathway:R-MMU-202433] Generation of second messenger molecules - Mus musculus
[Pathway:R-RNO-202433] Generation of second messenger molecules - Rattus norvegicus
[Pathway:R-CFA-202433] Generation of second messenger molecules - Canis familiaris
[Pathway:R-BTA-202433] Generation of second messenger molecules - Bos taurus
[Pathway:R-SSC-202433] Generation of second messenger molecules - Sus scrofa
[Pathway:R-DRE-202433] Generation of second messenger molecules - Danio rerio
[Pathway:R-XTR-202433] Generation of second messenger molecules - Xenopus tropicalis
[Pathway:R-DME-202433] Generation of second messenger molecules - Drosophila melanogaster
[Pathway:R-DDI-202433] Generation of second messenger molecules - Dictyostelium discoideum
[Pathway:R-SPO-202433] Generation of second messenger molecules - Schizosaccharomyces pombe
[Pathway:R-SCE-202433] Generation of second messenger molecules - Saccharomyces cerevisiae
[Pathway:R-PFA-202433] Generation of second messenger molecules - Plasmodium falciparum
[Pathway:R-GGA-202433] Generation of second messenger molecules - Gallus gallus
releaseDate
2008年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:214481] Trowsdale, J, 2008年02月26日 12:02:59
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-202433
summation
[Summation:202652] In addition to serving as a scaffold via auto-phosphorylatio...
updateTrackers
[UpdateTracker:9791110] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v32:[updateContainedRLE]
[UpdateTracker:9790418] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v33:[updateContainedRLE]
[UpdateTracker:9775893] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v78:[updateContainedRLE]
[UpdateTracker:9791321] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v31:[addHasEvent]
[UpdateTracker:9789136] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v38:[addLiteratureReference, modifyText]
[UpdateTracker:9783320] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v57:[updateContainedRLE]
[UpdateTracker:9781405] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v61:[updateContainedRLE]
[UpdateTracker:9776967] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v73:[modifyText]
[UpdateTracker:9788461] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v42:[updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-202403] TCR signaling
(updatedInstance)
[UpdateTracker:9791110] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v32:[updateContainedRLE]
[UpdateTracker:9790418] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v33:[updateContainedRLE]
[UpdateTracker:9775893] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v78:[updateContainedRLE]
[UpdateTracker:9791321] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v31:[addHasEvent]
[UpdateTracker:9789136] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v38:[addLiteratureReference, modifyText]
[UpdateTracker:9783320] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v57:[updateContainedRLE]
[UpdateTracker:9781405] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v61:[updateContainedRLE]
[UpdateTracker:9776967] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v73:[modifyText]
[UpdateTracker:9788461] Update Tracker - [Pathway:202433] Generation of second messenger molecules - v42:[updateContainedRLE]
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