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Autocatalytic phosphorylation of FGFR1c P252X mutant dimers Show undefined attributes

authored

[InstanceEdit:2105031] Rothfels, K, 2012年02月09日

catalystActivity

[CatalystActivity:2023453] protein tyrosine kinase activity of FGFR1c P252X mutant dimers bound to FGFs [plasma membrane]

category transition

compartment

created [InstanceEdit:2023454] Rothfels, K, 2011年12月07日

crossReference

dbId 2023455

disease

displayName Autocatalytic phosphorylation of FGFR1c P252X mutant dimers

edited

[InstanceEdit:2252592] Rothfels, K, 2012年05月16日

entityFunctionalStatus

[EntityFunctionalStatus:5654445] gain_of_function of FGFR1c P252X mutant dimers bound to FGFs [plasma membrane]

eventOf

[Pathway:R-HSA-1839122] Signaling by activated point mutants of FGFR1 - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

[LiteratureReference:2011820] Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Autocatalytic phosphorylation of FGFR1c P252X mutant dimers

normalReaction [Reaction:R-HSA-190429] Autocatalytic phosphorylation of FGFR1c

output

precedingEvent

[Reaction:R-HSA-2023451] FGFR1c P252X mutants bind ligand with enhanced affinity - Homo sapiens

releaseDate 2012年06月12日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:2248845] Ezzat, S, 2012年05月15日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-2023455

summation

[Summation:2023404] FGFR1 gain-of-function mutations at P252 that result in incr...

Referrals

(hasEvent)

[Pathway:R-HSA-1839122] Signaling by activated point mutants of FGFR1

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