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Schema
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Reaction
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Entries
Autocatalytic phosphorylation of FGFR1c P252X mutant dimers
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authored
[InstanceEdit:2105031] Rothfels, K, 2012年02月09日
catalystActivity
[CatalystActivity:2023453] protein tyrosine kinase activity of FGFR1c P252X mutant dimers bound to FGFs [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:2023454] Rothfels, K, 2011年12月07日
crossReference
[DatabaseIdentifier:11944971] Mondo:0005497
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
2023455
disease
[Disease:1500689] cancer
[Disease:2032940] bone development disease
displayName
Autocatalytic phosphorylation of FGFR1c P252X mutant dimers
edited
[InstanceEdit:2252592] Rothfels, K, 2012年05月16日
entityFunctionalStatus
[EntityFunctionalStatus:5654445] gain_of_function of FGFR1c P252X mutant dimers bound to FGFs [plasma membrane]
eventOf
[Pathway:R-HSA-1839122] Signaling by activated point mutants of FGFR1 - Homo sapiens
input
16 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-2050638] FGFR1c P252X mutant dimers bound to FGFs [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:2011820] Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Autocatalytic phosphorylation of FGFR1c P252X mutant dimers
normalReaction
[Reaction:R-HSA-190429] Autocatalytic phosphorylation of FGFR1c
output
[Complex:R-HSA-2050642] Activated FGFR1c P252X mutants [plasma membrane]
16 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent
[Reaction:R-HSA-2023451] FGFR1c P252X mutants bind ligand with enhanced affinity - Homo sapiens
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012年05月15日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2023455
summation
[Summation:2023404] FGFR1 gain-of-function mutations at P252 that result in incr...
Referrals
(hasEvent)
[Pathway:R-HSA-1839122] Signaling by activated point mutants of FGFR1
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