Reactome Pathway Database

Schema > CandidateSet > Entries

FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] Show undefined attributes

catalystActivities

[CatalystActivity:2023458] protein tyrosine kinase activity of FGFR1 mutant dimers with enhanced kinase activity [plasma membrane]

compartment

[Compartment:876] plasma membrane

consumedByEvent

[Reaction:R-HSA-2023460] Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity - Homo sapiens

created [InstanceEdit:2023434] Rothfels, K, 2011年12月07日

crossReference

dbId 2023433

disease

displayName FGFR1 mutant dimers with enhanced kinase activity [plasma membrane]

hasCandidate

[Complex:R-HSA-2023419] FGFR1 R576W mutant dimer [plasma membrane] - Homo sapiens

hasMember

inDisease true

maxDepth 3

modified [InstanceEdit:9962055] Matthews, Lisa, 2025年07月30日

name

FGFR1 mutant dimers with enhanced kinase activity

producedByEvent

[Reaction:R-HSA-2023456] Dimerization of FGFR1 point mutants with enhanced kinase activity - Homo sapiens

schemaClass CandidateSet

species

[Species:48887] Homo sapiens

stId R-HSA-2023433

updateTrackers

Referrals

(updatedInstance)

(output)

[Reaction:R-HSA-2023456] Dimerization of FGFR1 point mutants with enhanced kinase activity

(input)

[Reaction:R-HSA-2023460] Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity

(diseaseEntity)

[EntityFunctionalStatus:5654448] gain_of_function of FGFR1 mutant dimers with enhanced kinase activity [plasma membrane]

(physicalEntity)

[CatalystActivity:2023458] protein tyrosine kinase activity of FGFR1 mutant dimers with enhanced kinase activity [plasma membrane]

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