Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Pathway
>
Entries
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Show undefined attributes
Go to Details
authored
[InstanceEdit:198923] de Bono, B, 2007年07月08日 12:58:15
[InstanceEdit:5685601] Garapati, Phani Vijay, 2015年03月27日
created
[InstanceEdit:198934] de Bono, B, 2007年07月08日 13:23:45
dbId
198933
displayName
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
doi
10.3180/r-hsa-198933.2
eventOf
[Pathway:R-HSA-1280218] Adaptive Immune System - Homo sapiens
figure
[Figure:199175] /figures/immune_synapse_figure_1.jpg
goBiologicalProcess
[GO_BiologicalProcess:159969] regulation of immune response
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-198941] VCAM1 binds Integrin alpha4beta1 - Homo sapiens
[Reaction:R-HSA-9679740] ITGA4:ITGB1 binds natalizumab - Homo sapiens
[Reaction:R-HSA-198955] TCR complex interacts with peptide antigen-presenting MHC Class I - Homo sapiens
[Reaction:R-HSA-198958] KIR2DL2/3 interacting with HLA-C group 1 (Cw4) - Homo sapiens
[Reaction:R-HSA-198983] NKG2D homodimer interacting with ligands - Homo sapiens
[Reaction:R-HSA-199014] CD96 binds PVR - Homo sapiens
[Reaction:R-HSA-199032] MADCAM1-1 binds Integrin alpha4beta7 - Homo sapiens
[Reaction:R-HSA-199043] LILRs interact with MHC Class I - Homo sapiens
[Reaction:R-HSA-199046] Ligands bind L-selectin - Homo sapiens
[Reaction:R-HSA-199050] ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) - Homo sapiens
[Reaction:R-HSA-199062] KLRC1:KLRD1 heterodimer interacts with HLA-E - Homo sapiens
[Reaction:R-HSA-199079] Epithelial cadherin binds to KLRG1 - Homo sapiens
[Reaction:R-HSA-199112] CRTAM binds to NECL2 - Homo sapiens
[Reaction:R-HSA-199131] PVR binds CD226 - Homo sapiens
[Reaction:R-HSA-199144] Nectin 2 binds CD226 - Homo sapiens
[Reaction:R-HSA-199154] CD200 binds to CD200R - Homo sapiens
[Reaction:R-HSA-199169] MHC Class I interacts with CD160 - Homo sapiens
[Reaction:R-HSA-199161] Fc gamma receptors interact with antigen-bound IgG - Homo sapiens
[Reaction:R-HSA-199404] CD40L binds CD40 - Homo sapiens
[Reaction:R-HSA-199093] CXADR binds to AMICA1 - Homo sapiens
[Reaction:R-HSA-199518] C3d-complexed antigen binds to complement receptor - Homo sapiens
[Reaction:R-HSA-199558] KIR2DL1 interacting with HLA-C group 2 (Cw3) - Homo sapiens
[Reaction:R-HSA-199566] KIR3DL1 interacting with HLA Bw4 - Homo sapiens
[Reaction:R-HSA-199576] KIR3DL2 interacting with HLA-A3 - Homo sapiens
[Reaction:R-HSA-199579] KIR2DL4 interacting with HLA-G - Homo sapiens
[Reaction:R-HSA-199587] KIR2DS1 interacting with HLA-C group 2 (Cw4) - Homo sapiens
[Reaction:R-HSA-199583] KIR2DS2 interacting with HLA-C group 1 (Cw3) - Homo sapiens
[Reaction:R-HSA-5685606] CLEC2D binds KLRB1 - Homo sapiens
[Reaction:R-HSA-5685607] Sialic acid binds SIGLEC - Homo sapiens
[Reaction:R-HSA-5685600] viral HA binds NCRI - Homo sapiens
[Reaction:R-HSA-5685602] NCR3LG1 binds NCR3 - Homo sapiens
[Reaction:R-HSA-6793275] CMVPP65 binds NCR3 - Homo sapiens
[Reaction:R-HSA-5685608] CLEC2B binds KLRF1 dimer - Homo sapiens
[Reaction:R-HSA-5685604] SLAMF6 binds SLAMF6 - Homo sapiens
[Reaction:R-HSA-5685603] SAP and EAT2 binds SLAMF6 - Homo sapiens
[Reaction:R-HSA-5685605] SLAMF7 binds SLAMF7 - Homo sapiens
[Reaction:R-HSA-5686625] LAIR1 binds collagen - Homo sapiens
[Reaction:R-HSA-5696356] OSCAR binds collagen and SP-D - Homo sapiens
[Reaction:R-HSA-5696357] LAIR2 binds collagen - Homo sapiens
[Reaction:R-HSA-5696358] TREM,CD300 binds lipids - Homo sapiens
[Reaction:R-HSA-8850356] TCR binds microbial lipid-based antigen via CD1 - Homo sapiens
[Reaction:R-HSA-8850326] TCR binds self-lipid-based antigen via CD1 - Homo sapiens
[Reaction:R-HSA-8862090] PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G - Homo sapiens
[Reaction:R-HSA-8862084] PILRA,PILRB bind CD99 - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2020年09月24日
literatureReference
[LiteratureReference:200298] B cell recognition of membrane-bound antigen: an exquisite way of sensing ligands
[LiteratureReference:200306] Immune synapses in T-cell activation
[LiteratureReference:200314] Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses
[LiteratureReference:200299] The immunological synapse
[LiteratureReference:5687338] Functions of natural killer cells
[LiteratureReference:5690953] Comparative genomics of natural killer cell receptor gene clusters
maxDepth
2
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
orthologousEvent
[Pathway:R-CEL-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Caenorhabditis elegans
[Pathway:R-DME-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Drosophila melanogaster
[Pathway:R-GGA-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Gallus gallus
[Pathway:R-XTR-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Xenopus tropicalis
[Pathway:R-DRE-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Danio rerio
[Pathway:R-SSC-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Sus scrofa
[Pathway:R-BTA-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Bos taurus
[Pathway:R-CFA-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Canis familiaris
[Pathway:R-RNO-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Rattus norvegicus
[Pathway:R-MMU-198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - Mus musculus
releaseDate
2007年08月21日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:201344] Trowsdale, J, 2007年08月06日
[InstanceEdit:5692843] Barrow, Alexander D, 2015年05月12日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-198933
summation
[Summation:200289] A number of receptors and cell adhesion molecules play a key...
updateTrackers
[UpdateTracker:9787970] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v44:[updateContainedRLE]
[UpdateTracker:9784078] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v54:[addHasEvent, updateContainedRLE]
[UpdateTracker:9781757] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v60:[addHasEvent]
[UpdateTracker:9788612] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v41:[updateContainedRLE]
[UpdateTracker:9784766] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v53:[addHasEvent, addLiteratureReference]
[UpdateTracker:9779745] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v64:[updateContainedRLE]
[UpdateTracker:9787387] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v45:[updateContainedRLE]
[UpdateTracker:9789444] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v38:[addLiteratureReference, updateContainedRLE]
[UpdateTracker:9792166] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v23:[updateContainedRLE]
[UpdateTracker:9783561] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v56:[addHasEvent, updateContainedRLE]
[UpdateTracker:9776766] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v74:[addHasEvent, updateContainedRLE]
[UpdateTracker:9784909] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v52:[updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-1280218] Adaptive Immune System
(updatedInstance)
[UpdateTracker:9787970] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v44:[updateContainedRLE]
[UpdateTracker:9784078] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v54:[addHasEvent, updateContainedRLE]
[UpdateTracker:9781757] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v60:[addHasEvent]
[UpdateTracker:9788612] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v41:[updateContainedRLE]
[UpdateTracker:9784766] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v53:[addHasEvent, addLiteratureReference]
[UpdateTracker:9779745] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v64:[updateContainedRLE]
[UpdateTracker:9787387] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v45:[updateContainedRLE]
[UpdateTracker:9789444] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v38:[addLiteratureReference, updateContainedRLE]
[UpdateTracker:9792166] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v23:[updateContainedRLE]
[UpdateTracker:9783561] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v56:[addHasEvent, updateContainedRLE]
[UpdateTracker:9776766] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v74:[addHasEvent, updateContainedRLE]
[UpdateTracker:9784909] Update Tracker - [Pathway:198933] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell - v52:[updateContainedRLE]
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル