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Reaction
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Entries
ERK1/2/5 activate RSK1/2/3
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authored
[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006年10月10日
catalystActivity
[CatalystActivity:199864] protein serine/threonine kinase activity of p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:198764] 2007年07月10日 08:01:57
dbId
198746
displayName
ERK1/2/5 activate RSK1/2/3
edited
[InstanceEdit:3901124] D'Eustachio, P, 2013年07月15日
[InstanceEdit:4542306] Matthews, L, 2013年07月15日
eventOf
[Pathway:R-HSA-881907] Gastrin-CREB signalling pathway via PKC and MAPK - Homo sapiens
[Pathway:R-HSA-198753] ERK/MAPK targets - Homo sapiens
[Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP) - Homo sapiens
followingEvent
[Reaction:R-HSA-199895] RSK1/2/3 phosphorylates CREB at Serine 119 - Homo sapiens
[Reaction:R-HSA-3857328] RPS6KA1/2/3 phosphorylates CEBPB on S321 - Homo sapiens
input
6 ×
[SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
[DefinedSet:R-HSA-199858] Ribosomal protein S6 kinase [nucleoplasm]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:199940] The MAP kinase ERK5 binds to and phosphorylates p90 RSK
[LiteratureReference:444269] Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity
maxDepth
1
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
ERK1/2/5 activate RSK1/2/3
orthologousEvent
[Reaction:R-SCE-198746] ERK1/2/5 activate RSK1/2/3 - Saccharomyces cerevisiae
[Reaction:R-SPO-198746] ERK1/2/5 activate RSK1/2/3 - Schizosaccharomyces pombe
[Reaction:R-DDI-198746] ERK1/2/5 activate RSK1/2/3 - Dictyostelium discoideum
[Reaction:R-CEL-198746] ERK1/2/5 activate RSK1/2/3 - Caenorhabditis elegans
[Reaction:R-DME-198746] ERK1/2/5 activate RSK1/2/3 - Drosophila melanogaster
[Reaction:R-GGA-198746] ERK1/2/5 activate RSK1/2/3 - Gallus gallus
[Reaction:R-XTR-198746] ERK1/2/5 activate RSK1/2/3 - Xenopus tropicalis
[Reaction:R-SSC-198746] ERK1/2/5 activate RSK1/2/3 - Sus scrofa
[Reaction:R-BTA-198746] ERK1/2/5 activate RSK1/2/3 - Bos taurus
[Reaction:R-CFA-198746] ERK1/2/5 activate RSK1/2/3 - Canis familiaris
[Reaction:R-RNO-198746] ERK1/2/5 activate RSK1/2/3 - Rattus norvegicus
[Reaction:R-MMU-198746] ERK1/2/5 activate RSK1/2/3 - Mus musculus
output
6 ×
[SimpleEntity:R-ALL-113582] ADP [nucleoplasm]
[DefinedSet:R-HSA-199849] Phospho-Ribosomal protein S6 kinase [nucleoplasm]
precedingEvent
[Reaction:R-HSA-198714] ERK5 translocates to the nucleus - Homo sapiens
[BlackBoxEvent:R-HSA-5674387] Phosphorylated MAPKs translocate into the nucleus - Homo sapiens
[BlackBoxEvent:R-HSA-9610166] p-T,Y MAPK dimers translocate to nucleus - Homo sapiens
releaseDate
2008年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:202668] Greene, LA, 2007年11月08日 15:39:37
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-198746
summation
[Summation:199918] The p90 ribosomal S6 kinases (RSK1-4) comprise a family of s...
updateTrackers
[UpdateTracker:9778945] Update Tracker - [Reaction:198746] ERK1/2/5 activate RSK1/2/3 - v67:[addLiteratureReference]
Referrals
(updatedInstance)
[UpdateTracker:9778945] Update Tracker - [Reaction:198746] ERK1/2/5 activate RSK1/2/3 - v67:[addLiteratureReference]
(hasEvent)
[Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP)
[Pathway:R-HSA-881907] Gastrin-CREB signalling pathway via PKC and MAPK
[Pathway:R-HSA-198753] ERK/MAPK targets
(precedingEvent)
[Reaction:R-HSA-199895] RSK1/2/3 phosphorylates CREB at Serine 119
[Reaction:R-HSA-3857328] RPS6KA1/2/3 phosphorylates CEBPB on S321
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