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Schema
>
Reaction
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Entries
NOTCH1 binds DLL4
Show undefined attributes
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authored
[InstanceEdit:157021] Jassal, B, 2004年12月15日 13:08:03
category
binding
compartment
[Compartment:984] extracellular region
created
[InstanceEdit:1980040] Orlic-Milacic, M, 2011年11月08日
dbId
1980041
deleted
[Deleted:5694726] Deletion of instance: 157083
[Deleted:5694729] Deletion of instance: 157645
displayName
NOTCH1 binds DLL4
edited
[InstanceEdit:2106576] Orlic-Milacic, M, 2012年02月10日
[InstanceEdit:2098673] D'Eustachio, P, 2012年02月06日
entityOnOtherCell
[EntityWithAccessionedSequence:R-HSA-158437] DLL4 [plasma membrane] - Homo sapiens
eventOf
[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Homo sapiens
followingEvent
[Reaction:R-HSA-1980074] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 - Homo sapiens
inferredFrom
[Reaction:R-MMU-2053938] Dll4 binds Notch1 - Mus musculus
input
[EntityWithAccessionedSequence:R-HSA-158437] DLL4 [plasma membrane]
[DefinedSet:R-HSA-1911555] NOTCH1/Fringe-modified NOTCH1 [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
true
literatureReference
[LiteratureReference:2050621] The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
[LiteratureReference:2153441] Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment
[LiteratureReference:2235046] Delta-like 4 is indispensable in thymic environment specific for T cell development
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
NOTCH1 binds DLL4
output
[Complex:R-HSA-1911559] DLL4:NOTCH1 [plasma membrane]
precedingEvent
[BlackBoxEvent:R-HSA-1912382] Mature NOTCH heterodimer traffics to the plasma membrane - Homo sapiens
[BlackBoxEvent:R-HSA-1912379] Transport of fringe-modified NOTCH to plasma membrane - Homo sapiens
releaseDate
2012年03月13日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:165114] Joutel, A, 2004年12月15日
[InstanceEdit:2121207] Haw, R, 2012年02月06日
revised
[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011年11月14日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1980041
summation
[Summation:2053943] NOTCH1 is activated by DLL4 ligand expressed on a neighborin...
updateTrackers
[UpdateTracker:9788589] Update Tracker - [Reaction:1980041] NOTCH1 binds DLL4 - v41:[addLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9788589] Update Tracker - [Reaction:1980041] NOTCH1 binds DLL4 - v41:[addLiteratureReference, modifyText]
(replacementInstances)
[Deleted:5694726] Deletion of instance: 157083
[Deleted:5694729] Deletion of instance: 157645
(normalReaction)
[Reaction:R-HSA-2691211] NOTCH1 HD domain mutants bind DLL4
[Reaction:R-HSA-2900747] NOTCH1 HD+PEST domain mutants bind DLL4
[Reaction:R-HSA-2769000] NOTCH1 PEST domain mutants bind DLL4
[FailedReaction:R-HSA-2660815] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4
(hasEvent)
[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus
(precedingEvent)
[Reaction:R-HSA-1980074] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
(inferredTo)
[Reaction:R-MMU-2053938] Dll4 binds Notch1
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