Reactome | Metabolism of folate and pterines

created [InstanceEdit:196747] Jassal, B, 2007年04月24日 08:38:46

dbId 196757

displayName Metabolism of folate and pterines

eventOf

[Pathway:R-HSA-196849] Metabolism of water-soluble vitamins and cofactors - Homo sapiens

goBiologicalProcess [GO_BiologicalProcess:25846] folic acid metabolic process

hasDiagram true

hasEHLD false

hasEvent

[Reaction:R-HSA-8940134] FOLR2 binds FOLA - Homo sapiens
[BlackBoxEvent:R-HSA-8942344] FOLR2 transports FOLA from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-200646] Cytosolic folate export across the plasma membrane - Homo sapiens
[Reaction:R-HSA-200652] SLC19A1 transports 5-methyl-THF from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-197963] DHFR2 reduces FOLA to DHF - Homo sapiens
[Reaction:R-HSA-9709098] DHFR dimer reduces FOLA to DHF - Homo sapiens
[Reaction:R-HSA-9709109] DHFR dimer binds DHFR inhibitors - Homo sapiens
[Reaction:R-HSA-197972] DHF is reduced to tetrahydrofolate (THF) - Homo sapiens
[Reaction:R-HSA-197958] FPGS-2 transforms THF to THFPG - Homo sapiens
[Reaction:R-HSA-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Homo sapiens
[Reaction:R-HSA-200680] SLC25A32 transports THF from cytosol to mitochondrial matrix - Homo sapiens
[Reaction:R-HSA-200720] SLC25A32 transports THF from mitochondrial matrix to cytosol - Homo sapiens
[Reaction:R-HSA-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Homo sapiens
[Reaction:R-HSA-5694137] PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser - Homo sapiens
[Reaction:R-HSA-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Homo sapiens
[Reaction:R-HSA-200711] MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG - Homo sapiens
[Reaction:R-HSA-200661] MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG - Homo sapiens
[Reaction:R-HSA-200718] MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG - Homo sapiens
[Reaction:R-HSA-200735] SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG - Homo sapiens
[Reaction:R-HSA-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Homo sapiens
[Reaction:R-HSA-200651] 5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine - Homo sapiens
[Reaction:R-HSA-200644] 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ - Homo sapiens
[Reaction:R-HSA-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Homo sapiens
[Reaction:R-HSA-6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG - Homo sapiens
[Reaction:R-HSA-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Homo sapiens
[Reaction:R-HSA-6801462] MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF - Homo sapiens
[Reaction:R-HSA-6808487] ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG - Homo sapiens
[Reaction:R-HSA-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Homo sapiens
[BlackBoxEvent:R-HSA-6803255] HCOOH translocated from mitochondrial matrix to cytosol - Homo sapiens
[Reaction:R-HSA-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Homo sapiens

isInDisease false

isInferred false

lastUpdatedDate 2022年06月09日

literatureReference

maxDepth 2

modified [InstanceEdit:11064438] Weiser, Joel, 2025年08月28日

name

Metabolism of folate and pterines

orthologousEvent

releaseDate 2007年08月21日

releaseStatus UPDATED

reviewStatus [ReviewStatus:9821382] five stars

schemaClass Pathway

species

[Species:48887] Homo sapiens

stId R-HSA-196757

summation

[Summation:200700] Folates are essential cofactors that provide one-carbon moie...

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