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Schema
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Reaction
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Entries
Oxidation of cholesterol to 22beta-hydroxycholesterol
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authored
[InstanceEdit:378946] Jassal, Bijay, 2008年10月01日
catalystActivity
[CatalystActivity:193154] cholesterol monooxygenase (side-chain-cleaving) activity of CYP11A1:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix]
category
transition
compartment
[Compartment:5460] mitochondrial matrix
[Compartment:70616] mitochondrial inner membrane
created
[InstanceEdit:193053] Jassal, B, 2007年02月13日 10:16:33
dbId
193054
displayName
Oxidation of cholesterol to 22beta-hydroxycholesterol
edited
[InstanceEdit:196368] Jassal, B, 2007年04月20日 21:09:56
eventOf
[Pathway:R-HSA-196108] Pregnenolone biosynthesis - Homo sapiens
followingEvent
[Reaction:R-HSA-193065] Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol - Homo sapiens
input
[SimpleEntity:R-ALL-193156] CHOL [mitochondrial inner membrane]
[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
[SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix]
[SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:193076] Expression of catalytically active human cytochrome p450scc in Escherichia coli and mutagenesis of isoleucine-462
[LiteratureReference:193118] Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
Oxidation of cholesterol to 22beta-hydroxycholesterol
cholesterol + NADPH + H+ => 22beta-hydroxycholesterol + NADP+ + H2O
Oxidation of cholesterol
orthologousEvent
[Reaction:R-GGA-193054] Oxidation of cholesterol to 22beta-hydroxycholesterol - Gallus gallus
[Reaction:R-XTR-193054] Oxidation of cholesterol to 22beta-hydroxycholesterol - Xenopus tropicalis
[Reaction:R-DRE-193054] Oxidation of cholesterol to 22beta-hydroxycholesterol - Danio rerio
[Reaction:R-SSC-193054] Oxidation of cholesterol to 22beta-hydroxycholesterol - Sus scrofa
[Reaction:R-BTA-193054] Oxidation of cholesterol to 22beta-hydroxycholesterol - Bos taurus
[Reaction:R-CFA-193054] Oxidation of cholesterol to 22beta-hydroxycholesterol - Canis familiaris
[Reaction:R-RNO-193054] Oxidation of cholesterol to 22beta-hydroxycholesterol - Rattus norvegicus
[Reaction:R-MMU-193054] Oxidation of cholesterol to 22beta-hydroxycholesterol - Mus musculus
output
[SimpleEntity:R-ALL-193019] 22b-HCHOL [mitochondrial inner membrane]
[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
[SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
precedingEvent
[Reaction:R-HSA-8951850] TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane - Homo sapiens
[Reaction:R-HSA-196126] STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space - Homo sapiens
releaseDate
2007年05月15日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:196370] D'Eustachio, P, 2007年04月20日 21:11:21
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-193054
summation
[Summation:193150] Cholesterol and NADPH + H+ react to form 22beta-hydroxychole...
Referrals
(hasEvent)
[Pathway:R-HSA-196108] Pregnenolone biosynthesis
(precedingEvent)
[Reaction:R-HSA-193065] Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol
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