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Schema
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Pathway
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Entries
FGFR1c and Klotho ligand binding and activation
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authored
[InstanceEdit:190908] de Bono, B, 2007年01月10日 10:27:18
created
[InstanceEdit:190369] de Bono, B, 2007年01月02日 13:52:03
dbId
190374
deleted
[Deleted:6789867] Deletion of instance: 1307973
displayName
FGFR1c and Klotho ligand binding and activation
eventOf
[Pathway:R-HSA-190242] FGFR1 ligand binding and activation - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:24611] fibroblast growth factor receptor signaling pathway
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-190268] FGFR1c binds to Klotho-bound FGF23 - Homo sapiens
[Reaction:R-HSA-191062] Autocatalytic phosphorylation of Klotho-bound FGFR1c - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2023年09月13日
literatureReference
[LiteratureReference:190266] Klotho converts canonical FGF receptor into a specific receptor for FGF23
[LiteratureReference:1307942] Regulation of fibroblast growth factor-23 signaling by klotho
maxDepth
2
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
FGFR1c and Klotho ligand binding and activation
orthologousEvent
[Pathway:R-MMU-190374] FGFR1c and Klotho ligand binding and activation - Mus musculus
[Pathway:R-CEL-190374] FGFR1c and Klotho ligand binding and activation - Caenorhabditis elegans
[Pathway:R-DME-190374] FGFR1c and Klotho ligand binding and activation - Drosophila melanogaster
[Pathway:R-GGA-190374] FGFR1c and Klotho ligand binding and activation - Gallus gallus
[Pathway:R-XTR-190374] FGFR1c and Klotho ligand binding and activation - Xenopus tropicalis
[Pathway:R-DRE-190374] FGFR1c and Klotho ligand binding and activation - Danio rerio
[Pathway:R-SSC-190374] FGFR1c and Klotho ligand binding and activation - Sus scrofa
[Pathway:R-BTA-190374] FGFR1c and Klotho ligand binding and activation - Bos taurus
[Pathway:R-CFA-190374] FGFR1c and Klotho ligand binding and activation - Canis familiaris
[Pathway:R-RNO-190374] FGFR1c and Klotho ligand binding and activation - Rattus norvegicus
releaseDate
2007年02月28日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:192607] Mohammadi, M, 2007年02月06日 21:44:35
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-190374
summation
[Summation:190971] FGF23 is a member of the endocrine subfamily of FGFs. It is ...
updateTrackers
[UpdateTracker:9842327] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v86:[updateContainedRLE]
[UpdateTracker:9788966] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v39:[updateContainedRLE]
[UpdateTracker:9790979] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v32:[updateContainedRLE]
[UpdateTracker:9792383] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v22:[updateContainedRLE]
[UpdateTracker:9789771] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v37:[addLiteratureReference, modifyText, updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9842327] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v86:[updateContainedRLE]
[UpdateTracker:9788966] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v39:[updateContainedRLE]
[UpdateTracker:9790979] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v32:[updateContainedRLE]
[UpdateTracker:9792383] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v22:[updateContainedRLE]
[UpdateTracker:9789771] Update Tracker - [Pathway:190374] FGFR1c and Klotho ligand binding and activation - v37:[addLiteratureReference, modifyText, updateContainedRLE]
(replacementInstances)
[Deleted:6789867] Deletion of instance: 1307973
(hasEvent)
[Pathway:R-HSA-190242] FGFR1 ligand binding and activation
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