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Schema
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BlackBoxEvent
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Entries
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex
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authored
[InstanceEdit:187972] Matthews, L, 2006年09月29日 13:59:34
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:188343] Matthews, L, 2006年10月10日 13:52:41
dbId
188345
displayName
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex
edited
[InstanceEdit:188346] Matthews, L, 2006年10月10日 08:05:07
eventOf
[Pathway:R-HSA-1362277] Transcription of E2F targets under negative control by DREAM complex - Homo sapiens
[Pathway:R-HSA-69656] Cyclin A:Cdk2-associated events at S phase entry - Homo sapiens
[Pathway:R-HSA-69202] Cyclin E associated events during G1/S transition - Homo sapiens
followingEvent
[Reaction:R-HSA-174110] Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 - Homo sapiens
[Reaction:R-HSA-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Homo sapiens
[Reaction:R-HSA-170158] CDC25A dephosphorylates CCNA:CDK1 - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-4088168] CDC25A gene [nucleoplasm]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:188344] Cdc25 cell-cycle phosphatase as a target of c-myc
[LiteratureReference:141354] Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes
[LiteratureReference:141377] CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase
[LiteratureReference:1362256] Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex
output
[EntityWithAccessionedSequence:R-HSA-143487] CDC25A [nucleoplasm]
precedingEvent
[Reaction:R-HSA-8932400] MYC:MAX binds the CDC25A gene - Homo sapiens
[Reaction:R-HSA-8961961] E2F1 binds the CDC25A gene promoter - Homo sapiens
[Reaction:R-HSA-8964471] DREAM complex binds the CDC25A gene promoter - Homo sapiens
regulatedBy
[PositiveGeneExpressionRegulation:R-HSA-188376] Positive gene expression regulation by 'MYC:MAX:CDC25A gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:R-HSA-8961967] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:CDC25A gene [nucleoplasm]'
[NegativeGeneExpressionRegulation:R-HSA-8964503] Negative gene expression regulation by 'DREAM complex:CDC25A gene [nucleoplasm]'
regulationReference
[RegulationReference:9642317] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:CDC25A gene [nucleoplasm]' Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes
[RegulationReference:9642802] Negative gene expression regulation by 'DREAM complex:CDC25A gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
releaseDate
2006年04月24日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:188313] Coqueret, O, 2006年10月06日 08:59:06
[InstanceEdit:1538129] MacPherson, D, 2011年08月25日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-188345
summation
[Summation:188348] Binding of the MYC:MAX heterodimer to MYC response elements ...
updateTrackers
[UpdateTracker:9783000] Update Tracker - [BlackBoxEvent:188345] The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex - v58:[addInput, add_removeRegulator, modifyText]
[UpdateTracker:9781771] Update Tracker - [BlackBoxEvent:188345] The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex - v60:[addLiteratureReference, addRegulator, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9783000] Update Tracker - [BlackBoxEvent:188345] The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex - v58:[addInput, add_removeRegulator, modifyText]
[UpdateTracker:9781771] Update Tracker - [BlackBoxEvent:188345] The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex - v60:[addLiteratureReference, addRegulator, modifyText]
(hasEvent)
[Pathway:R-HSA-69656] Cyclin A:Cdk2-associated events at S phase entry
[Pathway:R-HSA-1362277] Transcription of E2F targets under negative control by DREAM complex
[Pathway:R-HSA-69202] Cyclin E associated events during G1/S transition
(precedingEvent)
[Reaction:R-HSA-174110] Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2
[Reaction:R-HSA-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
[Reaction:R-HSA-170158] CDC25A dephosphorylates CCNA:CDK1
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