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Schema
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Reaction
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Entries
GBA2 hydrolyzes GlcCer (plasma membrane)
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authored
[InstanceEdit:1605804] Jassal, Bijay, 2011年09月21日
catalystActivity
[CatalystActivity:1861763] glucosylceramidase activity of GBA2 [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:1861756] Jassal, B, 2011年10月31日
dbId
1861788
displayName
GBA2 hydrolyzes GlcCer (plasma membrane)
edited
[InstanceEdit:1605804] Jassal, Bijay, 2011年09月21日
eventOf
[Pathway:R-HSA-9840310] Glycosphingolipid catabolism - Homo sapiens
followingEvent
[Reaction:R-HSA-6785933] UGT8 transfers Gal from UDP-Gal to CERA - Homo sapiens
[Reaction:R-HSA-1606583] ASAH2 hydrolyzes ceramide (plasma membrane) - Homo sapiens
[Reaction:R-HSA-429786] SGMS2 transfers phosphocholine onto ceramide - Homo sapiens
[Reaction:R-HSA-1638845] CERK phosphorylates CERA to form C1P - Homo sapiens
input
[SimpleEntity:R-ALL-1861782] GlcCer [plasma membrane]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1861775] Molecular cloning and expression of human bile acid beta-glucosidase
[LiteratureReference:1861759] Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2
maxDepth
1
modified
[InstanceEdit:10948619] Weiser, Joel, 2025年08月27日
name
GBA2 hydrolyzes GlcCer (plasma membrane)
orthologousEvent
[Reaction:R-DDI-1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - Dictyostelium discoideum
[Reaction:R-CEL-1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - Caenorhabditis elegans
[Reaction:R-DME-1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - Drosophila melanogaster
[Reaction:R-GGA-1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - Gallus gallus
[Reaction:R-DRE-1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - Danio rerio
[Reaction:R-SSC-1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - Sus scrofa
[Reaction:R-BTA-1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - Bos taurus
[Reaction:R-CFA-1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - Canis familiaris
[Reaction:R-RNO-1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - Rattus norvegicus
[Reaction:R-MMU-1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - Mus musculus
output
[SimpleEntity:R-ALL-429807] CERA [plasma membrane]
[SimpleEntity:R-ALL-70113] Glc [cytosol]
releaseDate
2011年12月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1863068] Stephan, Ralf, 2011年10月31日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1861788
summation
[Summation:1861767] Human glucosylceramidase 2 (GBA2) hydrolyzes the glucosidic ...
updateTrackers
[UpdateTracker:9842274] Update Tracker - [Reaction:1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - v86:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9842274] Update Tracker - [Reaction:1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - v86:[modifyText]
(precedingEvent)
[Reaction:R-HSA-6785933] UGT8 transfers Gal from UDP-Gal to CERA
[Reaction:R-HSA-1638845] CERK phosphorylates CERA to form C1P
[Reaction:R-HSA-1606583] ASAH2 hydrolyzes ceramide (plasma membrane)
[Reaction:R-HSA-429786] SGMS2 transfers phosphocholine onto ceramide
(hasEvent)
[Pathway:R-HSA-9840310] Glycosphingolipid catabolism
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