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Schema
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Reaction
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Entries
Phosphorylation of STAT5 by cytosolic FGFR1 fusions
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authored
[InstanceEdit:2105031] Rothfels, K, 2012年02月09日
catalystActivity
[CatalystActivity:1839025] protein tyrosine kinase activity of cytosolic p-FGFR1 fusion mutant dimers [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:1839111] Rothfels, K, 2011年10月27日
crossReference
[DatabaseIdentifier:11944972] Mondo:0006311
[DatabaseIdentifier:11944973] Mondo:0002582
[DatabaseIdentifier:11944920] Mondo:0004967
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
1839112
disease
[Disease:1500689] cancer
[Disease:1614677] myelodysplastic myeloproliferative cancer
[Disease:1604519] subacute leukemia
[Disease:2317476] acute lymphocytic leukemia
displayName
Phosphorylation of STAT5 by cytosolic FGFR1 fusions
edited
[InstanceEdit:2252592] Rothfels, K, 2012年05月16日
entityFunctionalStatus
[EntityFunctionalStatus:9630091] gain_of_function of cytosolic p-FGFR1 fusion mutant dimers [cytosol]
eventOf
[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[DefinedSet:R-HSA-452094] STAT5A,STAT5B [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1637873] Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome
[LiteratureReference:1834981] ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5
[LiteratureReference:1606521] The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11)
[LiteratureReference:1834978] Critical role of STAT5 activation in transformation mediated by ZNF198-FGFR1
maxDepth
1
modified
[InstanceEdit:9832769] Orlic-Milacic, Marija, 2023年04月07日
name
Phosphorylation of STAT5 by cytosolic FGFR1 fusions
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[DefinedSet:R-HSA-507929] p-STAT5A, p-STAT5B [cytosol]
precedingEvent
[Reaction:R-HSA-1839065] Phosphorylation of cytosolic FGFR1 fusion dimers - Homo sapiens
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012年05月15日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1839112
summation
[Summation:1839087] Activation of a subset of FGFR1-fusions (ZMYM2, BCR, FGFR1OP...
Referrals
(hasEvent)
[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants
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