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Activated cytosolic FGFR1 fusions bind PIK3CA Show undefined attributes

authored

[InstanceEdit:2105031] Rothfels, K, 2012年02月09日

category binding

compartment

[Compartment:70101] cytosol

created [InstanceEdit:1839081] Rothfels, K, 2011年10月27日

crossReference

[DatabaseIdentifier:11944892] Mondo:0004992

dbId 1839080

disease

[Disease:1500689] cancer

displayName Activated cytosolic FGFR1 fusions bind PIK3CA

edited

[InstanceEdit:2252592] Rothfels, K, 2012年05月16日

entityFunctionalStatus

[EntityFunctionalStatus:5654441] gain_of_function of p-FGFR1 fusion mutant dimers:PIK3R1 [cytosol]

eventOf

[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants - Homo sapiens

followingEvent

[Reaction:R-HSA-1839091] Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Activated cytosolic FGFR1 fusions bind PIK3CA

normalReaction [Reaction:R-HSA-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA

output

[Complex:R-HSA-1839055] p-FGFR1 mutant fusions:PI3K [cytosol]

precedingEvent

[BlackBoxEvent:R-HSA-1839078] Cytosolic FGFR1 fusion proteins bind PIK3R1 - Homo sapiens

releaseDate 2012年06月12日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:2248845] Ezzat, S, 2012年05月15日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-1839080

summation

[Summation:2085608] Activation of the PI3K pathway has been demonstrated in the ...

Referrals

(hasEvent)

[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants

(precedingEvent)

[Reaction:R-HSA-1839091] Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3

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