Reactome Pathway Database

botC LC cleaves target cell STX1 Show undefined attributes

authored

[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006年06月15日 10:36:11

catalystActivity

[CatalystActivity:168781] metalloendopeptidase activity of botC LC:Zn2+ [cytosol]

catalystActivityReference [CatalystActivityReference:9643247] metalloendopeptidase activity of BoNT/C LC:Zn2+ [cytosol] Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: correlation with its blockade of catecholamine release

category transition

compartment

created [InstanceEdit:181561] Gopinathrao, G, 2006年06月14日 16:40:11

crossReference

[DatabaseIdentifier:11944965] Mondo:0005498

dbId 181567

deleted

disease

[Disease:3632909] botulism

displayName botC LC cleaves target cell STX1

edited

[InstanceEdit:181692] Gopinathrao, G, 2006年06月15日 22:12:29

eventOf

[Pathway:R-HSA-5250971] Toxicity of botulinum toxin type C (botC) - Homo sapiens

input

[DefinedSet:R-HSA-5250514] STX1 [plasma membrane]

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

botC LC cleaves target cell STX1

output

precedingEvent

[BlackBoxEvent:R-HSA-5246514] botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol - Homo sapiens

relatedSpecies

[Species:168825] Clostridium botulinum

releaseDate 2007年08月21日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

revised

[InstanceEdit:5263589] D'Eustachio, Peter, 2014年02月10日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-181567

summation

[Summation:181687] Botulinum toxin type C light chain (botC LC), in the cytosol...

updateTrackers

Referrals

(updatedInstance)

(replacementInstances)

(hasEvent)

[Pathway:R-HSA-5250971] Toxicity of botulinum toxin type C (botC)

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