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Schema
>
BlackBoxEvent
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Entries
Secretion and activation of the latent large complex of TGF-beta-1
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authored
[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006年02月02日
category
omitted
compartment
[Compartment:17963] Golgi lumen
[Compartment:984] extracellular region
created
[InstanceEdit:177100] Jassal, B, 2006年03月22日 11:41:32
dbId
177107
displayName
Secretion and activation of the latent large complex of TGF-beta-1
edited
[InstanceEdit:177100] Jassal, B, 2006年03月22日 11:41:32
eventOf
[Pathway:R-HSA-2173789] TGF-beta receptor signaling activates SMADs - Homo sapiens
input
[Complex:R-HSA-9736811] TGF-beta-1:LAP1 [Golgi lumen]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:178138] TGF-beta activation by traction?
[LiteratureReference:178136] Making sense of latent TGFbeta activation
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Secretion and activation of the latent large complex of TGF-beta-1
orthologousEvent
[BlackBoxEvent:R-CEL-177107] Secretion and activation of the latent large complex of TGF-beta-1 - Caenorhabditis elegans
[BlackBoxEvent:R-DME-177107] Secretion and activation of the latent large complex of TGF-beta-1 - Drosophila melanogaster
[BlackBoxEvent:R-GGA-177107] Secretion and activation of the latent large complex of TGF-beta-1 - Gallus gallus
[BlackBoxEvent:R-DRE-177107] Secretion and activation of the latent large complex of TGF-beta-1 - Danio rerio
[BlackBoxEvent:R-SSC-177107] Secretion and activation of the latent large complex of TGF-beta-1 - Sus scrofa
[BlackBoxEvent:R-BTA-177107] Secretion and activation of the latent large complex of TGF-beta-1 - Bos taurus
[BlackBoxEvent:R-CFA-177107] Secretion and activation of the latent large complex of TGF-beta-1 - Canis familiaris
[BlackBoxEvent:R-RNO-177107] Secretion and activation of the latent large complex of TGF-beta-1 - Rattus norvegicus
[BlackBoxEvent:R-MMU-177107] Secretion and activation of the latent large complex of TGF-beta-1 - Mus musculus
output
[Complex:R-HSA-2395236] TGFB1:LAP1 [extracellular region]
precedingEvent
[Reaction:R-HSA-170844] Latent TGF-beta-1 is cleaved by FURIN - Homo sapiens
releaseDate
2006年04月24日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:178196] Heldin, CH, 2006年04月18日 14:26:12
[InstanceEdit:2250308] Huang, Tao, 2012年05月14日
revised
[InstanceEdit:9736772] Blagotin?ek Cokan, Kaja, 2021年07月13日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-177107
summation
[Summation:177109] The large latent complex (LLC) of TGF-beta-1 (TGFB1) is secr...
updateTrackers
[UpdateTracker:9788689] Update Tracker - [BlackBoxEvent:177107] Secretion and activation of the latent large complex of TGF-beta-1 - v41:[modifyText]
[UpdateTracker:9775815] Update Tracker - [BlackBoxEvent:177107] Secretion and activation of the latent large complex of TGF-beta-1 - v78:[add_removeInput, modifyText]
[UpdateTracker:9789258] Update Tracker - [BlackBoxEvent:177107] Secretion and activation of the latent large complex of TGF-beta-1 - v38:[modifyText]
[UpdateTracker:9775444] Update Tracker - [BlackBoxEvent:177107] Secretion and activation of the latent large complex of TGF-beta-1 - v79:[add_removeOutput]
Referrals
(updatedInstance)
[UpdateTracker:9788689] Update Tracker - [BlackBoxEvent:177107] Secretion and activation of the latent large complex of TGF-beta-1 - v41:[modifyText]
[UpdateTracker:9775815] Update Tracker - [BlackBoxEvent:177107] Secretion and activation of the latent large complex of TGF-beta-1 - v78:[add_removeInput, modifyText]
[UpdateTracker:9789258] Update Tracker - [BlackBoxEvent:177107] Secretion and activation of the latent large complex of TGF-beta-1 - v38:[modifyText]
[UpdateTracker:9775444] Update Tracker - [BlackBoxEvent:177107] Secretion and activation of the latent large complex of TGF-beta-1 - v79:[add_removeOutput]
(hasEvent)
[Pathway:R-HSA-2173789] TGF-beta receptor signaling activates SMADs
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