Reactome Pathway Database

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SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling Show undefined attributes

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authored

[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006年02月02日

category binding

compartment

[Compartment:7660] nucleoplasm

created [InstanceEdit:173513] Jassal, B, 2006年02月10日 14:02:35

dbId 173481

displayName SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling

edited

eventOf

[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Homo sapiens

followingEvent

[Reaction:R-HSA-2186741] SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL - Homo sapiens

input

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:10778922] Weiser, Joel, 2025年08月27日

name

SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling

negativePrecedingEvent

[NegativePrecedingEvent:9754420] Futile Cycle: Ubiquitination of SKI/SKIL by RNF111/SMURF2

orthologousEvent

output

[Complex:R-HSA-177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm]

precedingEvent

[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens

releaseDate 2006年04月24日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

revised

[InstanceEdit:2186634] Orlic-Milacic, M, 2012年04月04日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-173481

summation

[Summation:176015] SKI and SKIL (SNO) are able to recruit NCOR and possibly oth...

updateTrackers

Referrals

(updatedInstance)

(hasEvent)

[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity

(precedingEvent)

[Reaction:R-HSA-2186741] SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL

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