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Schema
>
BlackBoxEvent
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Entries
SREBP1A,1C,2 translocates to the nucleus
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authored
[InstanceEdit:1655770] May, B, 2011年09月28日
category
omitted
compartment
[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created
[InstanceEdit:1655841] May, B, 2011年10月13日
dbId
1655831
displayName
SREBP1A,1C,2 translocates to the nucleus
edited
[InstanceEdit:1655770] May, B, 2011年09月28日
eventOf
[Pathway:R-HSA-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF) - Homo sapiens
followingEvent
[Reaction:R-HSA-2065539] SREBP1A,1C,2:Importin beta-1 dissociates - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:11054] protein import into nucleus
input
[Complex:R-HSA-2065556] SREBP1A,1C,2:Importin beta-1 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1368888] SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
[LiteratureReference:1655558] Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment
[LiteratureReference:1655686] Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta
[LiteratureReference:1655711] The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor
[LiteratureReference:1655706] Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip
[LiteratureReference:1655600] Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution
[LiteratureReference:1655621] Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers
[LiteratureReference:9717132] Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
SREBP1A,1C,2 translocates to the nucleus
SREBF1A,1C,2 translocates to the nucleus
orthologousEvent
[BlackBoxEvent:R-CEL-1655831] SREBP1A,1C,2 translocates to the nucleus - Caenorhabditis elegans
[BlackBoxEvent:R-DME-1655831] SREBP1A,1C,2 translocates to the nucleus - Drosophila melanogaster
[BlackBoxEvent:R-GGA-1655831] SREBP1A,1C,2 translocates to the nucleus - Gallus gallus
[BlackBoxEvent:R-XTR-1655831] SREBP1A,1C,2 translocates to the nucleus - Xenopus tropicalis
[BlackBoxEvent:R-SSC-1655831] SREBP1A,1C,2 translocates to the nucleus - Sus scrofa
[BlackBoxEvent:R-BTA-1655831] SREBP1A,1C,2 translocates to the nucleus - Bos taurus
[BlackBoxEvent:R-CFA-1655831] SREBP1A,1C,2 translocates to the nucleus - Canis familiaris
[BlackBoxEvent:R-RNO-1655831] SREBP1A,1C,2 translocates to the nucleus - Rattus norvegicus
[BlackBoxEvent:R-MMU-1655831] SREBP1A,1C,2 translocates to the nucleus - Mus musculus
output
[Complex:R-HSA-2065543] SREBP1A,1C,2:Importin beta-1 [nucleoplasm]
precedingEvent
[Reaction:R-HSA-2065550] SREBP1A,1C,2 binds Importin beta-1 - Homo sapiens
releaseDate
2012年09月18日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2457630] Liang, Guosheng, 2012年08月25日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-1655831
summation
[Summation:1655782] The N-terminal domain of SREBP1A,1C,2 (SREBF1A,1C,2) dimeriz...
updateTrackers
[UpdateTracker:9776146] Update Tracker - [BlackBoxEvent:1655831] SREBP1A,1C,2 translocates to the nucleus - v77:[addLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9776146] Update Tracker - [BlackBoxEvent:1655831] SREBP1A,1C,2 translocates to the nucleus - v77:[addLiteratureReference, modifyText]
(hasEvent)
[Pathway:R-HSA-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF)
(precedingEvent)
[Reaction:R-HSA-2065539] SREBP1A,1C,2:Importin beta-1 dissociates
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