Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
Phosphorylation and release of IRF3
Show undefined attributes
Go to Details
authored
[InstanceEdit:1606299] Shamovsky, V, 2011年09月21日
category
dissociation
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:1606339] Shamovsky, V, 2011年09月21日
dbId
1606327
displayName
Phosphorylation and release of IRF3
edited
[InstanceEdit:2134527] Shamovsky, V, 2012年02月23日
eventOf
[Pathway:R-HSA-1606341] IRF3 mediated activation of type 1 IFN - Homo sapiens
followingEvent
[Reaction:R-HSA-2395992] p-T,4S-IRF3 is dimerized - Homo sapiens
input
10 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-1606328] dsDNA:ZBP1:pS-172-TBK:IRF3 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:434014] Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch
[LiteratureReference:433975] Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300
[LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Phosphorylation and release of IRF3
output
10 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-1606333] dsDNA:ZBP1:pS-172-TBK1 [cytosol]
2 ×
[EntityWithAccessionedSequence:R-HSA-166258] p-4S,T404-IRF3 [cytosol]
precedingEvent
[Reaction:R-HSA-1606345] Recruitment of IRF3 to activated ZBP1:TBK1 - Homo sapiens
regulatedBy
[NegativeRegulation:R-HSA-3249373] Negative regulation by 'NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol]'
regulationReference
[RegulationReference:9641587] Negative regulation by 'NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol]' NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4
relatedSpecies
[Species:8982084] Human alphaherpesvirus 2
[Species:2671791] Human cytomegalovirus
releaseDate
2012年03月13日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2023355] D'Eustachio, P, 2011年12月07日
[InstanceEdit:2129340] Upton, JW, Mocarski, ES, 2012年02月19日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1606327
summation
[Summation:2054083] IRF3 is activated through a two-step phosphorylation in the ...
updateTrackers
[UpdateTracker:9788482] Update Tracker - [Reaction:1606327] Phosphorylation and release of IRF3 - v42:[add_removeOutput]
[UpdateTracker:9787439] Update Tracker - [Reaction:1606327] Phosphorylation and release of IRF3 - v45:[addRegulator]
Referrals
(updatedInstance)
[UpdateTracker:9788482] Update Tracker - [Reaction:1606327] Phosphorylation and release of IRF3 - v42:[add_removeOutput]
[UpdateTracker:9787439] Update Tracker - [Reaction:1606327] Phosphorylation and release of IRF3 - v45:[addRegulator]
(precedingEvent)
[NegativePrecedingEvent:9764705] Negative relationship: Phosphorylation and release of IRF3
[NegativePrecedingEvent:9764717] Drug molecule: Phosphorylation and release of IRF3
[Reaction:R-HSA-2395992] p-T,4S-IRF3 is dimerized
[NegativePrecedingEvent:9764710] Futile Cycle: Phosphorylation and release of IRF3
(hasEvent)
[Pathway:R-HSA-1606341] IRF3 mediated activation of type 1 IFN
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル