Reactome Pathway Database

Schema > Reaction > Entries

Furin cleaves pro-factor VII to factor VII Show undefined attributes

catalystActivity

[CatalystActivity:156993] serine-type endopeptidase activity of FURIN [Golgi membrane]

category transition

compartment

created [InstanceEdit:159817] D'Eustachio, P, 2005年03月17日 16:24:57

dbId 159868

displayName Furin cleaves pro-factor VII to factor VII

eventOf

[Pathway:R-HSA-159782] Removal of aminoterminal propeptides from gamma-carboxylated proteins - Homo sapiens

input

[EntityWithAccessionedSequence:R-HSA-159767] pro-factor VII [Golgi lumen]

isInDisease false

isInferred false

literatureReference

[LiteratureReference:6807230] PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway

maxDepth 1

modified [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

name

Furin cleaves pro-factor VII to factor VII
pro-factor VII -> factor VII + factor VII propeptide

orthologousEvent

output

precedingEvent

[BlackBoxEvent:R-HSA-159783] Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus - Homo sapiens

releaseDate 2005年06月13日

reviewStatus [ReviewStatus:9821382] five stars

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-159868

summation

[Summation:179104] Furin, associated with the Golgi membrane, cleaves pro-facto...

updateTrackers

[UpdateTracker:9783845] Update Tracker - [Reaction:159868] Furin cleaves pro-factor VII to factor VII - v55:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)

[UpdateTracker:9783845] Update Tracker - [Reaction:159868] Furin cleaves pro-factor VII to factor VII - v55:[addLiteratureReference, modifyText]

(hasEvent)

[Pathway:R-HSA-159782] Removal of aminoterminal propeptides from gamma-carboxylated proteins

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