Reactome Pathway Database

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Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements Show undefined attributes

authored

[InstanceEdit:1535901] May, B, 2011年08月26日

category binding

compartment

[Compartment:7660] nucleoplasm

created [InstanceEdit:1535900] May, B, 2011年08月26日

dbId 1535903

displayName Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements

edited

[InstanceEdit:1535901] May, B, 2011年08月26日

eventOf

[Pathway:R-HSA-1181150] Signaling by NODAL - Homo sapiens

input

isChimeric false

isInDisease false

isInferred false

literatureReference

[LiteratureReference:1535902] Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells

maxDepth 1

modified [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

name

Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements

orthologousEvent

output

[Complex:R-HSA-1535906] SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm]

precedingEvent

[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens

releaseDate 2011年09月20日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:1529118] Peng, C, 2011年08月24日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-1535903

summation

[Summation:1535905] FOXO3 (FOXO3A) interacts with phospho-SMAD2 and phospho-SMAD...

Referrals

(hasEvent)

[Pathway:R-HSA-1181150] Signaling by NODAL

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