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1-acyl LPE is acylated to PE by LPEAT
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authored
[InstanceEdit:1602345] Williams, MG, 2011年09月14日
catalystActivity
[CatalystActivity:1524039] 1-acylglycerol-3-phosphate O-acyltransferase activity of LPEAT [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:70101] cytosol
created
[InstanceEdit:1482525] Williams, MG, 2011年08月12日
dbId
1482667
displayName
1-acyl LPE is acylated to PE by LPEAT
edited
[InstanceEdit:1482514] Williams, MG, 2011年08月12日
eventOf
[Pathway:R-HSA-1482839] Acyl chain remodelling of PE - Homo sapiens
followingEvent
[Reaction:R-HSA-1482884] PE is hydrolyzed to 1-acyl LPE by PLA2[2] - Homo sapiens
[Reaction:R-HSA-1483174] PE is methylated to PC by PEMT - Homo sapiens
[Reaction:R-HSA-1482828] PE is hydrolyzed to 2-acyl LPE by PLA2[4] - Homo sapiens
[Reaction:R-HSA-1482892] PE is hydrolyzed to 2-acyl LPE by PLA2G4C - Homo sapiens
[Reaction:R-HSA-1482887] PE is hydrolyzed to 1-acyl LPE by PLA2[3] - Homo sapiens
[Reaction:R-HSA-1483089] PE is converted to PS by PTDSS2 - Homo sapiens
input
[SimpleEntity:R-ALL-1498738] 1-acyl LPE [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1482645] Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity
[LiteratureReference:429002] Identification and characterization of a major liver lysophosphatidylcholine acyltransferase
[LiteratureReference:1482630] Characterization of human lysophospholipid acyltransferase 3
[LiteratureReference:429001] Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils
[LiteratureReference:1482687] Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2
[LiteratureReference:1482536] Substrate preferences of a lysophosphatidylcholine acyltransferase highlight its role in phospholipid remodeling
maxDepth
1
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
1-acyl LPE is acylated to PE by LPEAT
orthologousEvent
[Reaction:R-PFA-1482667] 1-acyl LPE is acylated to PE by LPEAT - Plasmodium falciparum
[Reaction:R-MMU-1482667] 1-acyl LPE is acylated to PE by LPEAT - Mus musculus
[Reaction:R-SCE-1482667] 1-acyl LPE is acylated to PE by LPEAT - Saccharomyces cerevisiae
[Reaction:R-SPO-1482667] 1-acyl LPE is acylated to PE by LPEAT - Schizosaccharomyces pombe
[Reaction:R-DDI-1482667] 1-acyl LPE is acylated to PE by LPEAT - Dictyostelium discoideum
[Reaction:R-CEL-1482667] 1-acyl LPE is acylated to PE by LPEAT - Caenorhabditis elegans
[Reaction:R-DME-1482667] 1-acyl LPE is acylated to PE by LPEAT - Drosophila melanogaster
[Reaction:R-GGA-1482667] 1-acyl LPE is acylated to PE by LPEAT - Gallus gallus
[Reaction:R-XTR-1482667] 1-acyl LPE is acylated to PE by LPEAT - Xenopus tropicalis
[Reaction:R-SSC-1482667] 1-acyl LPE is acylated to PE by LPEAT - Sus scrofa
[Reaction:R-BTA-1482667] 1-acyl LPE is acylated to PE by LPEAT - Bos taurus
[Reaction:R-CFA-1482667] 1-acyl LPE is acylated to PE by LPEAT - Canis familiaris
[Reaction:R-RNO-1482667] 1-acyl LPE is acylated to PE by LPEAT - Rattus norvegicus
output
[SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
[SimpleEntity:R-ALL-1500581] PE [endoplasmic reticulum membrane]
precedingEvent
[Reaction:R-HSA-1482884] PE is hydrolyzed to 1-acyl LPE by PLA2[2] - Homo sapiens
[Reaction:R-HSA-1482887] PE is hydrolyzed to 1-acyl LPE by PLA2[3] - Homo sapiens
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1482667
summation
[Summation:1482538] At the endoplasmic reticulum (ER) membrane, lysophospholipid...
Referrals
(precedingEvent)
[Reaction:R-HSA-1483174] PE is methylated to PC by PEMT
[Reaction:R-HSA-1482828] PE is hydrolyzed to 2-acyl LPE by PLA2[4]
[Reaction:R-HSA-1482892] PE is hydrolyzed to 2-acyl LPE by PLA2G4C
[Reaction:R-HSA-1483089] PE is converted to PS by PTDSS2
[Reaction:R-HSA-1482884] PE is hydrolyzed to 1-acyl LPE by PLA2[2]
[Reaction:R-HSA-1482887] PE is hydrolyzed to 1-acyl LPE by PLA2[3]
(hasEvent)
[Pathway:R-HSA-1482839] Acyl chain remodelling of PE
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