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Schema
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Reaction
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Entries
PGG2 is reduced to PGH2 by PTGS1
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authored
[InstanceEdit:378946] Jassal, Bijay, 2008年10月01日
catalystActivity
[CatalystActivity:140358] peroxidase activity of PTGS1 dimer [endoplasmic reticulum membrane]
catalystActivityReference
[CatalystActivityReference:9915548] peroxidase activity of PTGS1 dimer [endoplasmic reticulum membrane] Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arachidonic acid
category
transition
compartment
[Compartment:17957] endoplasmic reticulum lumen
[Compartment:12045] endoplasmic reticulum membrane
created
[InstanceEdit:140352] Jassal, B, 2004年08月13日 10:35:27
crossReference
[DatabaseIdentifier:12611259] Rhea:42601
[DatabaseIdentifier:9915541] RHEA:42600
dbId
140359
displayName
PGG2 is reduced to PGH2 by PTGS1
edited
[InstanceEdit:350358] Jassal, Bijay, 2008年05月19日
eventOf
[Pathway:R-HSA-140180] COX reactions - Homo sapiens
[Pathway:R-HSA-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) - Homo sapiens
followingEvent
[Reaction:R-HSA-2161613] PGH2 is degraded to 12S-HHT and MDA by TBXAS1 - Homo sapiens
[Reaction:R-HSA-2161620] PGH2 is isomerised to PGD2 by PTGDS - Homo sapiens
[BlackBoxEvent:R-HSA-2299725] PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol - Homo sapiens
[Reaction:R-HSA-76500] TBXAS1 isomerises PGH2 to TXA2 - Homo sapiens
[Reaction:R-HSA-76496] PTGIS, CYP8A1 isomerise PGH2 to PGI2 - Homo sapiens
input
[SimpleEntity:R-ALL-9915557] hydrogen donor [endoplasmic reticulum lumen]
[SimpleEntity:R-ALL-140357] PGG2 [endoplasmic reticulum lumen]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:140567] Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis
[LiteratureReference:2162129] Human cyclooxygenase-2 cDNA
[LiteratureReference:2162103] Differential allosteric regulation of prostaglandin H synthase 1 and 2 by arachidonic acid
[LiteratureReference:2162150] Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
PGG2 is reduced to PGH2 by PTGS1
AH2 + prostaglandin G2 = A + H2O + prostaglandin H2
Peroxidative reduction of PGG2 to PGH2
orthologousEvent
[Reaction:R-GGA-140359] PGG2 is reduced to PGH2 by PTGS1 - Gallus gallus
[Reaction:R-XTR-140359] PGG2 is reduced to PGH2 by PTGS1 - Xenopus tropicalis
[Reaction:R-DRE-140359] PGG2 is reduced to PGH2 by PTGS1 - Danio rerio
[Reaction:R-SSC-140359] PGG2 is reduced to PGH2 by PTGS1 - Sus scrofa
[Reaction:R-BTA-140359] PGG2 is reduced to PGH2 by PTGS1 - Bos taurus
[Reaction:R-CFA-140359] PGG2 is reduced to PGH2 by PTGS1 - Canis familiaris
[Reaction:R-RNO-140359] PGG2 is reduced to PGH2 by PTGS1 - Rattus norvegicus
[Reaction:R-MMU-140359] PGG2 is reduced to PGH2 by PTGS1 - Mus musculus
output
[SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen]
[SimpleEntity:R-ALL-9915551] hydrogen acceptor [endoplasmic reticulum lumen]
[SimpleEntity:R-ALL-30138] PGH2 [endoplasmic reticulum lumen]
precedingEvent
[Reaction:R-HSA-140355] Arachidonate is oxidised to PGG2 by PTGS1 - Homo sapiens
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2008年06月30日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2569042] Rush, MG, 2012年11月10日
[InstanceEdit:9917333] Hill, David P, 2024年08月02日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-140359
summation
[Summation:179032] Prostaglandin G/H synthase 1 (PTGS1) exhibits a dual catalyt...
updateTrackers
[UpdateTracker:9919391] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v90:[add_removeInput, removeOutput]
[UpdateTracker:9788652] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v41:[addInput, addLiteratureReference, modifyText]
[UpdateTracker:9791924] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v25:[modifyText]
[UpdateTracker:9788332] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v42:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9919391] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v90:[add_removeInput, removeOutput]
[UpdateTracker:9788652] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v41:[addInput, addLiteratureReference, modifyText]
[UpdateTracker:9791924] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v25:[modifyText]
[UpdateTracker:9788332] Update Tracker - [Reaction:140359] PGG2 is reduced to PGH2 by PTGS1 - v42:[modifyText]
(precedingEvent)
[Reaction:R-HSA-2161613] PGH2 is degraded to 12S-HHT and MDA by TBXAS1
[Reaction:R-HSA-2161620] PGH2 is isomerised to PGD2 by PTGDS
[BlackBoxEvent:R-HSA-2299725] PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol
[Reaction:R-HSA-76500] TBXAS1 isomerises PGH2 to TXA2
[Reaction:R-HSA-76496] PTGIS, CYP8A1 isomerise PGH2 to PGI2
(hasEvent)
[Pathway:R-HSA-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
[Pathway:R-HSA-140180] COX reactions
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