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Schema
>
Complex
>
Entries
Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
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catalystActivities
[CatalystActivity:1225930] guanyl-nucleotide exchange factor activity of Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:1225853] Orlic-Milacic, Marija, 2011年03月02日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
1225856
disease
[Disease:1500689] cancer
displayName
Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
hasComponent
[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
[Complex:R-HSA-1225854] Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane]
inDisease
true
includedLocation
[Compartment:70101] cytosol
isChimeric
false
maxDepth
8
modified
[InstanceEdit:5638336] Orlic-Milacic, Marija, 2014年11月13日
name
Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1
GRB2:SOS1:Phospho-SHC1:Phospho-EGFRmutKD:HSP90:CDC37
GRB2:SOS1-Phospho-SHC1:Active dimers of phospho-EGFR KD mutants:HSP90:CDC37
producedByEvent
[Reaction:R-HSA-1225961] Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex - Homo sapiens
schemaClass
Complex
species
[Species:48887] Homo sapiens
stId
R-HSA-1225856
updateTrackers
[UpdateTracker:9871952] Update Tracker - [Complex:1225856] Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - v41:[removeCompartment, updateContainedComponent]
[UpdateTracker:9898153] Update Tracker - [Complex:1225856] Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9873216] Update Tracker - [Complex:1225856] Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9892295] Update Tracker - [Complex:1225856] Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
Referrals
(updatedInstance)
[UpdateTracker:9871952] Update Tracker - [Complex:1225856] Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - v41:[removeCompartment, updateContainedComponent]
[UpdateTracker:9898153] Update Tracker - [Complex:1225856] Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - v63:[updateContainedComponent]
[UpdateTracker:9873216] Update Tracker - [Complex:1225856] Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - v42:[updateContainedComponent]
[UpdateTracker:9892295] Update Tracker - [Complex:1225856] Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - v53:[updateContainedComponent]
(output)
[Reaction:R-HSA-1225961] Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex
(diseaseEntity)
[EntityFunctionalStatus:5637720] gain_of_function of Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
(physicalEntity)
[CatalystActivity:1225930] guanyl-nucleotide exchange factor activity of Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
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