Reactome Pathway Database

Schema > EntityWithAccessionedSequence > Entries

p-6Y-EGFR L858R;T790M [plasma membrane] Show undefined attributes

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:1182981] Orlic-Milacic, Marija, 2011年02月09日

crossReference

[DatabaseIdentifier:11944945] Mondo:0005233

dbId 1182984

disease

[Disease:1247848] non-small cell lung carcinoma

displayName p-6Y-EGFR L858R;T790M [plasma membrane]

endCoordinate 1210

hasModifiedResidue

inDisease true

literatureReference

[LiteratureReference:1169414] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity

maxDepth 1

memberOf

[CandidateSet:R-HSA-1182982] Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] - Homo sapiens

modified [InstanceEdit:3662293] Orlic-Milacic, M, 2013年06月06日

name

p-6Y-EGFR L858R;T790M
Phosphorylated Epidermal Growth Factor Receptor L858R T790M
p-6Y-EGFR Leu858Arg;Thr790Met

referenceEntity [ReferenceGeneProduct:uniprot:P00533] UniProt:P00533 EGFR

referenceType ReferenceGeneProduct

schemaClass EntityWithAccessionedSequence

species [Species:48887] Homo sapiens

stId R-HSA-1182984

startCoordinate 25

updateTrackers

[UpdateTracker:9888203] Update Tracker - [EntityWithAccessionedSequence:1182984] p-6Y-EGFR L858R;T790M [plasma membrane] - v46:[modifyName]

Referrals

(updatedInstance)

[UpdateTracker:9888203] Update Tracker - [EntityWithAccessionedSequence:1182984] p-6Y-EGFR L858R;T790M [plasma membrane] - v46:[modifyName]

(hasMember)

[CandidateSet:R-HSA-1182982] Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane]

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