Reactome Pathway Database

Schema > EntityWithAccessionedSequence > Entries

EGFR E746_A750del;T790M [plasma membrane] Show undefined attributes

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:1181398] Orlic-Milacic, Marija, 2011年02月07日

crossReference

dbId 1181399

disease

displayName EGFR E746_A750del;T790M [plasma membrane]

endCoordinate 1210

hasModifiedResidue

inDisease true

literatureReference

[LiteratureReference:1181035] Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
[LiteratureReference:1181387] Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors

maxDepth 1

memberOf

[CandidateSet:R-HSA-1182967] Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] - Homo sapiens

modified [InstanceEdit:9626688] Orlic-Milacic, Marija, 2018年10月29日

name

EGFR E746_A750del;T790M
Epidermal Growth Factor Receptor E746_A750del T790M
EGFR Glu746_Ala750del;Thr790Met

referenceEntity [ReferenceGeneProduct:uniprot:P00533] UniProt:P00533 EGFR

referenceType ReferenceGeneProduct

schemaClass EntityWithAccessionedSequence

species [Species:48887] Homo sapiens

stId R-HSA-1181399

startCoordinate 25

summation

[Summation:1181400] Secondary mutation T790M in EGFR E746_A750del mutant confers...

updateTrackers

Referrals

(updatedInstance)

(hasMember)

[CandidateSet:R-HSA-1182967] Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane]

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