Reactome Pathway Database

Schema > EntityWithAccessionedSequence > Entries

EGFR L858R;T790M [plasma membrane] Show undefined attributes

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:1181385] Orlic-Milacic, Marija, 2011年02月07日

crossReference

dbId 1181386

disease

displayName EGFR L858R;T790M [plasma membrane]

endCoordinate 1210

hasModifiedResidue

inDisease true

literatureReference

[LiteratureReference:1169414] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity
[LiteratureReference:1181387] Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors

maxDepth 1

memberOf

[CandidateSet:R-HSA-1182967] Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] - Homo sapiens

modified [InstanceEdit:3662293] Orlic-Milacic, M, 2013年06月06日

name

EGFR L858R;T790M
Epidermal Growth Factor Receptor L858R T790M
EGFR Leu858Arg;Thr790Met

referenceEntity [ReferenceGeneProduct:uniprot:P00533] UniProt:P00533 EGFR

referenceType ReferenceGeneProduct

schemaClass EntityWithAccessionedSequence

species [Species:48887] Homo sapiens

stId R-HSA-1181386

startCoordinate 25

summation

[Summation:1181388] Secondary mutation T790M in EGFR L858R mutant confers TKI re...

updateTrackers

[UpdateTracker:9888161] Update Tracker - [EntityWithAccessionedSequence:1181386] EGFR L858R;T790M [plasma membrane] - v46:[modifyName]

Referrals

(updatedInstance)

[UpdateTracker:9888161] Update Tracker - [EntityWithAccessionedSequence:1181386] EGFR L858R;T790M [plasma membrane] - v46:[modifyName]

(hasMember)

[CandidateSet:R-HSA-1182967] Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane]

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