Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Pathway
>
Entries
GPVI-mediated activation cascade
Show undefined attributes
Go to Details
created
[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004年09月25日 17:06:19
dbId
114604
deleted
[Deleted:9028752] Deletion of instance: 139943
displayName
GPVI-mediated activation cascade
doi
10.3180/R-HSA-114604.2
edited
[InstanceEdit:445674] Jupe, S, 2009年11月03日
[InstanceEdit:9032145] Orlic-Milacic, Marija, 2017年12月06日
eventOf
[Pathway:R-HSA-76002] Platelet activation, signaling and aggregation - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-114600] Fyn/Lyn-mediated phosphorylation of FcR1 gamma - Homo sapiens
[Reaction:R-HSA-139842] Binding of Syk tyrosine kinase - Homo sapiens
[Reaction:R-HSA-453200] SYK autophosphorylates - Homo sapiens
[Reaction:R-HSA-453183] p-Y348-SYK dissociates - Homo sapiens
[Reaction:R-HSA-437932] p-Y348-SYK binds VAV family - Homo sapiens
[Reaction:R-HSA-437936] p-Y348-SYK phosphorylates VAV family - Homo sapiens
[Reaction:R-HSA-442273] VAV1 is a GEF for Rho/Rac family GTPases - Homo sapiens
[Reaction:R-HSA-442291] VAV2 is a GEF for Rho/Rac family kinases - Homo sapiens
[Reaction:R-HSA-442314] VAV3 is a GEF for Rho/Rac family kinases - Homo sapiens
[Reaction:R-HSA-434836] Syk/Lck phosphorylate LAT - Homo sapiens
[Reaction:R-HSA-429449] Syk activation leads to SLP-76 activation - Homo sapiens
[BlackBoxEvent:R-HSA-429497] SLP-76 stimulates PLC gamma 2 - Homo sapiens
[Reaction:R-HSA-430158] p-SLP-76 binds VAV - Homo sapiens
[Reaction:R-HSA-114689] PLC gamma 2-mediated PIP2 hydrolysis - Homo sapiens
[Reaction:R-HSA-434637] PI(3,4,5)P3 binds VAV1,2,3 - Homo sapiens
[Reaction:R-HSA-434633] PIP2 binds inhibiting VAV - Homo sapiens
[BlackBoxEvent:R-HSA-437118] GPVI stimulates PI3K beta, gamma - Homo sapiens
[Reaction:R-HSA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Homo sapiens
[Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane - Homo sapiens
[Reaction:R-HSA-437192] PDPK1 binds PRKCZ - Homo sapiens
[Reaction:R-HSA-437195] PDPK1 activates PRKCZ - Homo sapiens
[Reaction:R-HSA-5684169] G6B binds PTPN6,PTPN11 - Homo sapiens
[Reaction:R-HSA-5684836] CLEC1B dimer binds PDPN - Homo sapiens
[BlackBoxEvent:R-HSA-5684806] Unknown kinase phosphorylates CLEC1B dimer:PDPN - Homo sapiens
[Reaction:R-HSA-5684801] p-Y7-CLEC1B dimer:PDPN binds SYK - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2019年03月25日
literatureReference
[LiteratureReference:210193] Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling
[LiteratureReference:210067] GPVI and integrin alphaIIb beta3 signaling in platelets
maxDepth
2
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
GPVI-mediated activation cascade
orthologousEvent
[Pathway:R-MMU-114604] GPVI-mediated activation cascade - Mus musculus
[Pathway:R-RNO-114604] GPVI-mediated activation cascade - Rattus norvegicus
[Pathway:R-CFA-114604] GPVI-mediated activation cascade - Canis familiaris
[Pathway:R-BTA-114604] GPVI-mediated activation cascade - Bos taurus
[Pathway:R-SSC-114604] GPVI-mediated activation cascade - Sus scrofa
[Pathway:R-DRE-114604] GPVI-mediated activation cascade - Danio rerio
[Pathway:R-XTR-114604] GPVI-mediated activation cascade - Xenopus tropicalis
[Pathway:R-GGA-114604] GPVI-mediated activation cascade - Gallus gallus
[Pathway:R-DME-114604] GPVI-mediated activation cascade - Drosophila melanogaster
[Pathway:R-CEL-114604] GPVI-mediated activation cascade - Caenorhabditis elegans
[Pathway:R-DDI-114604] GPVI-mediated activation cascade - Dictyostelium discoideum
[Pathway:R-SPO-114604] GPVI-mediated activation cascade - Schizosaccharomyces pombe
[Pathway:R-SCE-114604] GPVI-mediated activation cascade - Saccharomyces cerevisiae
[Pathway:R-PFA-114604] GPVI-mediated activation cascade - Plasmodium falciparum
releaseDate
2004年10月27日
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-114604
summation
[Summation:432300] The GPVI receptor is a complex of the GPVI protein with Fc e...
updateTrackers
[UpdateTracker:9784495] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v54:[updateContainedRLE]
[UpdateTracker:9792182] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v23:[updateContainedRLE]
[UpdateTracker:9790195] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v34:[addHasEvent]
[UpdateTracker:9791326] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v31:[addHasEvent, updateContainedRLE]
[UpdateTracker:9784854] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v53:[updateContainedRLE]
[UpdateTracker:9782354] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v59:[updateContainedRLE]
[UpdateTracker:9780163] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v64:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9784011] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v55:[addHasEvent]
[UpdateTracker:9782723] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v58:[updateContainedRLE]
[UpdateTracker:9786357] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v49:[updateContainedRLE]
[UpdateTracker:9778610] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v68:[updateContainedRLE]
[UpdateTracker:9791458] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v30:[addLiteratureReference, addSummation, add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9787559] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v44:[updateContainedRLE]
[UpdateTracker:9791215] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v32:[updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-76002] Platelet activation, signaling and aggregation
(replacementInstances)
[Deleted:9028752] Deletion of instance: 139943
(updatedInstance)
[UpdateTracker:9784495] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v54:[updateContainedRLE]
[UpdateTracker:9792182] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v23:[updateContainedRLE]
[UpdateTracker:9790195] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v34:[addHasEvent]
[UpdateTracker:9791326] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v31:[addHasEvent, updateContainedRLE]
[UpdateTracker:9784854] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v53:[updateContainedRLE]
[UpdateTracker:9782354] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v59:[updateContainedRLE]
[UpdateTracker:9780163] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v64:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9784011] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v55:[addHasEvent]
[UpdateTracker:9782723] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v58:[updateContainedRLE]
[UpdateTracker:9786357] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v49:[updateContainedRLE]
[UpdateTracker:9778610] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v68:[updateContainedRLE]
[UpdateTracker:9791458] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v30:[addLiteratureReference, addSummation, add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9787559] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v44:[updateContainedRLE]
[UpdateTracker:9791215] Update Tracker - [Pathway:114604] GPVI-mediated activation cascade - v32:[updateContainedRLE]
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル