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Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2 Show undefined attributes

authored

[InstanceEdit:1094913] Shamovsky, V, 2010年11月30日

catalystActivity

[CatalystActivity:977242] protein serine/threonine kinase activity of IRAK2 : p-IRAK4 :MyD88 : activated TLR [plasma membrane]

category transition

compartment

created [InstanceEdit:977249] Shamovsky, V, 2010年10月15日

dbId 977239

displayName Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2

edited

[InstanceEdit:1221606] Shamovsky, V, 2011年02月24日

eventOf

[Pathway:R-GGA-977240] MyD88 cascade initiated on plasma membrane - Gallus gallus

inferredFrom

[Reaction:R-HSA-975861] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex - Homo sapiens

input

isInDisease false

isInferred true

literatureReference

[LiteratureReference:446698] Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2

output

precedingEvent

[Reaction:R-GGA-977237] IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex - Gallus gallus

relatedSpecies

[Species:451465] Salmonella typhimurium

releaseDate 2011年03月15日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:1112618] D'Eustachio, P, 2010年12月06日

schemaClass Reaction

species

[Species:49591] Gallus gallus

stId R-GGA-977239

summation

[Summation:570878] In mammals activated IRAK4 phosphorylates both IRAK1 and IRA...

Referrals

(hasEvent)

[Pathway:R-GGA-977240] MyD88 cascade initiated on plasma membrane

(inferredTo)

[Reaction:R-HSA-975861] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex

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