Reactome Pathway Database

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VDAC1 transports PYR from cytosol to mitochondrial intermembrane space Show undefined attributes

catalystActivity

[CatalystActivity:10764009] voltage-gated monoatomic anion channel activity of VDAC1 [mitochondrial outer membrane]

category transition

compartment

created [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

dbId 10764011

displayName VDAC1 transports PYR from cytosol to mitochondrial intermembrane space

eventOf

[Pathway:R-GGA-70268] Pyruvate metabolism - Gallus gallus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Homo sapiens

input

[SimpleEntity:R-ALL-29398] PYR [cytosol]

isInDisease false

isInferred true

maxDepth 1

name

VDAC1 transports PYR from cytosol to mitochondrial intermembrane space

output

[SimpleEntity:R-ALL-9012375] PYR [mitochondrial intermembrane space]

precedingEvent

regulatedBy

[NegativeRegulation:10068675] Negative regulation by 'NO [cytosol]'

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49591] Gallus gallus

stId R-GGA-9012374

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-GGA-70268] Pyruvate metabolism

(inferredTo)

[Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space

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