Reactome Pathway Database

Schema > Reaction > Entries

CYP1A2 S-demethylates 6MMP Show undefined attributes

catalystActivity

[CatalystActivity:10685409] monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]

category transition

compartment

[Compartment:17960] smooth endoplasmic reticulum

created [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

dbId 10685413

displayName CYP1A2 S-demethylates 6MMP

eventOf

[Pathway:R-GGA-156581] Methylation - Gallus gallus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-GGA-158609] TPMT transfers CH3 from AdoMet to 6MP - Gallus gallus

inferredFrom

[Reaction:R-HSA-76386] CYP1A2 S-demethylates 6MMP - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

CYP1A2 S-demethylates 6MMP
S-atom dealkylation of 6-methylmercaptopurine

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49591] Gallus gallus

stId R-GGA-76386

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-GGA-156581] Methylation

(precedingEvent)

[Reaction:R-GGA-158609] TPMT transfers CH3 from AdoMet to 6MP

(inferredTo)

[Reaction:R-HSA-76386] CYP1A2 S-demethylates 6MMP

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