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Schema
>
Polymer
>
Entries
K63polyUb [cytosol]
Show undefined attributes
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compartment
[Compartment:70101] cytosol
componentOf
[Complex:R-GGA-975171] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] - Gallus gallus
[Complex:R-GGA-975171] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] - Gallus gallus
[Complex:R-GGA-975171] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] - Gallus gallus
[Complex:R-GGA-937008] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] - Gallus gallus
[Complex:R-GGA-937008] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] - Gallus gallus
[Complex:R-GGA-937008] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] - Gallus gallus
[Complex:R-GGA-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] - Gallus gallus
[Complex:R-GGA-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] - Gallus gallus
[Complex:R-GGA-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] - Gallus gallus
[Complex:R-GGA-9645449] ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] - Gallus gallus
[Complex:R-GGA-9645449] ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] - Gallus gallus
consumedByEvent
[BlackBoxEvent:R-GGA-5696547] STAMBPL1 is a deubiquitinase - Gallus gallus
[Reaction:R-GGA-5691431] PSMD14 cleaves K63-linked ubiquitin - Gallus gallus
[Reaction:R-GGA-5688797] ATXN3 family cleave Ub chains - Gallus gallus
[BlackBoxEvent:R-GGA-5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK - Gallus gallus
[Reaction:R-GGA-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Gallus gallus
[Reaction:R-GGA-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Gallus gallus
[Reaction:R-GGA-9931430] MIB2-mediated K63-ubiquitination of CD274 - Gallus gallus
[BlackBoxEvent:R-GGA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - Gallus gallus
[Reaction:R-GGA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Gallus gallus
[Reaction:R-GGA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Gallus gallus
[Reaction:R-GGA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Gallus gallus
[Reaction:R-GGA-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Gallus gallus
[Reaction:R-GGA-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Gallus gallus
[Reaction:R-GGA-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex - Gallus gallus
[Reaction:R-GGA-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex - Gallus gallus
[Reaction:R-GGA-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Gallus gallus
[Reaction:R-GGA-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Gallus gallus
[Reaction:R-GGA-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Gallus gallus
created
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
dbId
10690661
displayName
K63polyUb [cytosol]
inDisease
false
inferredFrom
[Polymer:R-HSA-6783297] Short K63polyUb [cytosol] - Homo sapiens
[Polymer:R-HSA-450152] K63polyUb [cytosol] - Homo sapiens
maxDepth
3
memberOf
[DefinedSet:R-GGA-5689096] PolyUb [cytosol] - Gallus gallus
name
K63polyUb
producedByEvent
[Reaction:R-GGA-5688797] ATXN3 family cleave Ub chains - Gallus gallus
[Polymerisation:R-GGA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Gallus gallus
[Polymerisation:R-GGA-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Gallus gallus
[Polymerisation:R-GGA-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Gallus gallus
[Reaction:R-GGA-5690856] TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 - Gallus gallus
[Reaction:R-GGA-8869506] TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 - Gallus gallus
[Reaction:R-GGA-6781779] USP13 deubiquitinates BECN1,USP10 - Gallus gallus
[Reaction:R-GGA-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG - Gallus gallus
[Reaction:R-GGA-6781814] USP19 deubiquitinates RNF123 - Gallus gallus
[Reaction:R-GGA-5691439] BRISC complex deubiquitinates NLRP3 - Gallus gallus
repeatedUnit
[DefinedSet:R-GGA-450143] K63-Ub [cytosol]
schemaClass
Polymer
species
[Species:49591] Gallus gallus
stId
R-GGA-450152
summation
[Summation:9965818] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Referrals
(output)
[Reaction:R-GGA-5690856] TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
[Reaction:R-GGA-8869506] TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6
[Reaction:R-GGA-6781779] USP13 deubiquitinates BECN1,USP10
[Reaction:R-GGA-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
[Reaction:R-GGA-6781814] USP19 deubiquitinates RNF123
[Reaction:R-GGA-5691439] BRISC complex deubiquitinates NLRP3
[Reaction:R-GGA-5688797] ATXN3 family cleave Ub chains
[Polymerisation:R-GGA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
[Polymerisation:R-GGA-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation
[Polymerisation:R-GGA-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains
(input)
[BlackBoxEvent:R-GGA-5696547] STAMBPL1 is a deubiquitinase
[Reaction:R-GGA-5691431] PSMD14 cleaves K63-linked ubiquitin
[Reaction:R-GGA-5688797] ATXN3 family cleave Ub chains
[Reaction:R-GGA-9931430] MIB2-mediated K63-ubiquitination of CD274
[BlackBoxEvent:R-GGA-5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
[BlackBoxEvent:R-GGA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1
[Reaction:R-GGA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
[Reaction:R-GGA-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex
[Reaction:R-GGA-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
[Reaction:R-GGA-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
[Reaction:R-GGA-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex
(inferredTo)
[Polymer:R-HSA-6783297] Short K63polyUb [cytosol]
[Polymer:R-HSA-450152] K63polyUb [cytosol]
(hasComponent)
[Complex:R-GGA-975171] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane]
[Complex:R-GGA-975099] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane]
[Complex:R-GGA-936946] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane]
[Complex:R-GGA-936954] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane]
[Complex:R-GGA-9645449] ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol]
[Complex:R-GGA-9645445] ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol]
[Complex:R-GGA-937008] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane]
[Complex:R-GGA-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane]
[Complex:R-GGA-847073] K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol]
[Complex:R-GGA-937060] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol]
(hasMember)
[DefinedSet:R-GGA-5689096] PolyUb [cytosol]
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