Reactome Pathway Database

Schema > Reaction > Entries

PHLPP dephosphorylates S473 in AKT Show undefined attributes

catalystActivity

[CatalystActivity:10696064] protein serine/threonine phosphatase activity of PHLPP (Mn2+ cofactor) [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

dbId 10696066

displayName PHLPP dephosphorylates S473 in AKT

eventOf

[Pathway:R-GGA-199418] Negative regulation of the PI3K/AKT network - Gallus gallus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

goBiologicalProcess [GO_BiologicalProcess:263612] negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

inferredFrom

[Reaction:R-HSA-199425] PHLPP dephosphorylates S473 in AKT - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

PHLPP dephosphorylates S473 in AKT

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49591] Gallus gallus

stId R-GGA-199425

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-GGA-199418] Negative regulation of the PI3K/AKT network

(inferredTo)

[Reaction:R-HSA-199425] PHLPP dephosphorylates S473 in AKT

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