Reactome Pathway Database

Schema > Reaction > Entries

Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines Show undefined attributes

catalystActivity

[CatalystActivity:10725491] procollagen-lysine 5-dioxygenase activity of Lysyl hydroxylases [endoplasmic reticulum membrane]

category transition

compartment

[Compartment:12045] endoplasmic reticulum membrane

created [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

dbId 10725493

displayName Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines

eventOf

[Pathway:R-GGA-1650814] Collagen biosynthesis and modifying enzymes - Gallus gallus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[BlackBoxEvent:R-GGA-8948232] Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases - Gallus gallus

inferredFrom

[Reaction:R-HSA-1981104] Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49591] Gallus gallus

stId R-GGA-1981104

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-GGA-1650814] Collagen biosynthesis and modifying enzymes

(precedingEvent)

[BlackBoxEvent:R-GGA-8948232] Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases

(inferredTo)

[Reaction:R-HSA-1981104] Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines

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