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CYP11A1 cleaves 20a,22b-DHCHOL Show undefined attributes

catalystActivity

[CatalystActivity:10694313] cholesterol monooxygenase (side-chain-cleaving) activity of CYP11A1:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix]

category transition

compartment

created [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

dbId 10694361

displayName CYP11A1 cleaves 20a,22b-DHCHOL

eventOf

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-193101] CYP11A1 cleaves 20a,22b-DHCHOL - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

CYP11A1 cleaves 20a,22b-DHCHOL
(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced (adrenodoxin) => 4-methylpentanal + 2 H2O + 2 oxidized (adrenodoxin) + pregnenolone
20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde
20alpha,22beta-hydroxycholesterol + NADPH + H+ + O2 => pregnenolone + isocaproaldehyde + NADP+ + H2O

output

precedingEvent

[Reaction:R-GGA-193065] Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol - Gallus gallus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49591] Gallus gallus

stId R-GGA-193101

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

(inferredTo)

[Reaction:R-HSA-193101] CYP11A1 cleaves 20a,22b-DHCHOL

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