Reactome Pathway Database

Schema > Reaction > Entries

ITCH polyubiquitinates TP73 Show undefined attributes

catalystActivity

[CatalystActivity:10592536] ubiquitin protein ligase activity of ITCH [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10541496] Weiser, Joel, 2025年08月27日

dbId 10592538

displayName ITCH polyubiquitinates TP73

eventOf

[Pathway:R-DRE-8939236] RUNX1 regulates transcription of genes involved in differentiation of HSCs - Danio rerio

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[BlackBoxEvent:R-DRE-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH - Danio rerio

inferredFrom

[Reaction:R-HSA-8956684] ITCH polyubiquitinates TP73 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

ITCH polyubiquitinates TP73

output

[Complex:R-DRE-8957254] PolyUb-TP73 tetramer [cytosol]

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:68323] Danio rerio

stId R-DRE-8956684

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-DRE-8939236] RUNX1 regulates transcription of genes involved in differentiation of HSCs

(precedingEvent)

[BlackBoxEvent:R-DRE-8957265] 26S proteasome degrades TP73 polyubiquitinated by ITCH

(inferredTo)

[Reaction:R-HSA-8956684] ITCH polyubiquitinates TP73

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