Reactome Pathway Database

Schema > Reaction > Entries

PAK1-3 phosphorylates VE-cadherin Show undefined attributes

catalystActivity

[CatalystActivity:10576547] protein serine/threonine kinase activity of p-S,T-PAK1,2,3 [cytosol]

category transition

compartment

created [InstanceEdit:10541496] Weiser, Joel, 2025年08月27日

dbId 10576549

displayName PAK1-3 phosphorylates VE-cadherin

eventOf

[Pathway:R-DRE-5218920] VEGFR2 mediated vascular permeability - Danio rerio

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-5357477] PAK1-3 phosphorylates VE-cadherin - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

PAK1-3 phosphorylates VE-cadherin

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:68323] Danio rerio

stId R-DRE-5357477

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-DRE-5218920] VEGFR2 mediated vascular permeability

(inferredTo)

[Reaction:R-HSA-5357477] PAK1-3 phosphorylates VE-cadherin

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