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IDH2 dimer decarboxylates isocitrate Show undefined attributes

catalystActivity

[CatalystActivity:10559179] isocitrate dehydrogenase (NADP+) activity of IDH2 dimer [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:10541496] Weiser, Joel, 2025年08月27日

dbId 10559186

displayName IDH2 dimer decarboxylates isocitrate

eventOf

[Pathway:R-DRE-71403] Citric acid cycle (TCA cycle) - Danio rerio

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

inferredFrom

[Reaction:R-HSA-450984] IDH2 dimer decarboxylates isocitrate - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

IDH2 dimer decarboxylates isocitrate
D-threo-isocitrate + NADP(+) => 2-oxoglutarate + CO2 + NADPH

output

precedingEvent

regulatedBy

[NegativeRegulation:10559187] Negative regulation by 'AcK-IDH2 dimer [mitochondrial matrix]'

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:68323] Danio rerio

stId R-DRE-450984

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)

(hasEvent)

[Pathway:R-DRE-71403] Citric acid cycle (TCA cycle)

(inferredTo)

[Reaction:R-HSA-450984] IDH2 dimer decarboxylates isocitrate

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