Reactome Pathway Database

Schema > Reaction > Entries

ROS,RNS oxidize ACO2:4Fe-4S Show undefined attributes

catalystActivity

[CatalystActivity:10861958] molecular sensor activity of ACO2:4Fe-4S [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:10778922] Weiser, Joel, 2025年08月27日

dbId 10861960

displayName ROS,RNS oxidize ACO2:4Fe-4S

eventOf

[Pathway:R-DME-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Drosophila melanogaster

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-DME-9854405] Frataxin transfers Fe2+ to ACO2 - Drosophila melanogaster

inferredFrom

[Reaction:R-HSA-9854368] ROS,RNS oxidize ACO2:4Fe-4S - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

ROS,RNS oxidize ACO2:4Fe-4S

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:56210] Drosophila melanogaster

stId R-DME-9854368

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-DME-9854311] Maturation of TCA enzymes and regulation of TCA cycle

(precedingEvent)

[Reaction:R-DME-9854405] Frataxin transfers Fe2+ to ACO2

(inferredTo)

[Reaction:R-HSA-9854368] ROS,RNS oxidize ACO2:4Fe-4S

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