Reactome Pathway Database

Schema > Reaction > Entries

CYP2D6 4-hydroxylates debrisoquine Show undefined attributes

catalystActivity

[CatalystActivity:10795465] oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen of Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane]

category transition

compartment

created [InstanceEdit:10778922] Weiser, Joel, 2025年08月27日

dbId 10795467

displayName CYP2D6 4-hydroxylates debrisoquine

eventOf

[Pathway:R-DME-211981] Xenobiotics - Drosophila melanogaster

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-211966] CYP2D6 4-hydroxylates debrisoquine - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

CYP2D6 4-hydroxylates debrisoquine

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:56210] Drosophila melanogaster

stId R-DME-211966

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-DME-211981] Xenobiotics

(inferredTo)

[Reaction:R-HSA-211966] CYP2D6 4-hydroxylates debrisoquine

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