Reactome Pathway Database

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TRIF (TICAM1)-mediated TLR4 signaling Show undefined attributes

created [InstanceEdit:10948619] Weiser, Joel, 2025年08月27日

dbId 10999838

displayName TRIF (TICAM1)-mediated TLR4 signaling

eventOf

[Pathway:R-DDI-166166] MyD88-independent TLR4 cascade - Dictyostelium discoideum

evidenceType [EvidenceType:9965817] inferred by electronic annotation

goBiologicalProcess [GO_BiologicalProcess:1221070] TRIF-dependent toll-like receptor signaling pathway

hasDiagram false

hasEHLD false

hasEvent

inferredFrom

[Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling - Homo sapiens

isInDisease false

isInferred true

maxDepth 6

name

TRIF (TICAM1)-mediated TLR4 signaling

releaseDate 2025年09月18日

schemaClass Pathway

species

[Species:170941] Dictyostelium discoideum

stId R-DDI-937061

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-DDI-166166] MyD88-independent TLR4 cascade

(inferredTo)

[Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling

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